#AntagonisticSignalingModulation

Generation of antagonistic biparatopic anti-CD30 antibody from an agonistic antibody by precise epitope determination and utilization of structural characteristics of CD30 molecule Statement of Significance: Thirty-six bivalent biparatopic antibodies targeting pairs of nine distinct topographical epitopes distributed over CD30 were de

Antibody Therapeutics (IF=4.5, Oxford University Press)
🔥Research Highlight-Creating an antagonistic biparatopic anti-CD30 antibody from an agonistic one via epitope mapping and CD30 structural features
academic.oup.com/abt/article/...
#CD30EpitopeMapping #AntagonisticSignalingModulation