Challenges and solutions for upstream processing of complex biologics Statement of Significance Complex molecules present hurdles in expression, assembly, and posttranslational modification, thereby limiting titer and quality

Antibody Therapeutics (IF=4.5, Oxford University Press) ⚡ Research Highlight - Challenges and solutions for upstream processing of complex biologics
academic.oup.com/abt/article/...

#mab #mabs #antibody #antibodies #antibodydiscovery #antibodytherapeutics #biologics #openaccess

Protein language models enable prediction of polyreactivity of monospecific, bispecific, and heavy-chain-only antibodies Statement of Significance: Our study yields insights on building infrastructures to support machine learning activities and training models for critical as

Antibody Therapeutics (IF=4.5, Oxford University Press) ⚡ Research Highlight - Protein language models enable prediction of polyreactivity of monospecific, bispecific, and heavy-chain-only antibodies
academic.oup.com/abt/article/...
#biologics #deeplearning #proteinlanguagemodel

Near-infrared photoimmunotherapy: mechanisms, applications, and future perspectives in cancer research Statement of Significance: Photoimmunotherapy (PIT) is a tumor-targeted therapy with minimal off-target effects. Recent advances in technology have expande

Antibody Therapeutics (IF=4.5, Oxford University Press) ⚡ Review Highlight - Near-infrared photoimmunotherapy: mechanisms, applications, and future perspectives in cancer research
academic.oup.com/abt/article/...
#photoimmunotherapy #photoimmunoconjugates #photodynamictherapy

Practical advice in the development of a lyophilized protein drug product Statement of Significance: This review offers practical advice on the critical aspects of lyophilized protein drug product development, including considera

Antibody Therapeutics (IF=4.5, Oxford University Press) ⚡ Review Highlight - Practical advice in the development of a lyophilized protein drug product
academic.oup.com/abt/article/...
#lyophilizedproteindrugproduct #formulationoptimization #lyophilizationcycledevelopment

CAR NK cell therapy for solid tumors: potential and challenges Statement of Significance This review highlights the promise of CAR NK cell therapy as a safer, off-the-shelf alternative to CAR-T cells for solid tumors.

Antibody Therapeutics (IF=4.5, Oxford University Press) ⚡ Review Highlight - CAR NK cell therapy for solid tumors: potential and challenges
academic.oup.com/abt/article/...
#antibodies #antibodydiscovery #antibodytherapeutics #biologics #naturalkillercells #CAR #CARNK

Reprogramming the tumor microenvironment: synergistic mechanisms of antibody–drug conjugates and immune checkpoint inhibitors Statement of Significance This study elucidates the synergistic mechanisms of antibody–drug conjugates and immune checkpoint inhibitors in tumor microenvir

Antibody Therapeutics (IF=4.5, Oxford University Press) ⚡ Reprogramming the tumor microenvironment: synergistic mechanisms of antibody–drug conjugates and immune checkpoint inhibitors
academic.oup.com/abt/article/...
#antibodydiscovery #tumormicroenvironment #TME

A novel bispecific antibody CVL006 superior to AK112 for dual targeting of PD-L1 and VEGF in cancer therapy Statement of Significance This project developed CVL006, a PD-L1/VEGF bispecific antibody combining an anti-PD-L1 VHH domain with an anti-VEGF IgG1. Precli

Antibody Therapeutics (IF=4.5, Oxford University Press) ⚡ A novel bispecific antibody CVL006 superior to AK112 for dual targeting of PD-L1 and VEGF in cancer therapy
academic.oup.com/abt/article/...
#bispecific #bispecificantibody #bispecificantibodies #bsab #VEGF #AK112

Antibody Therapeutics (IF=4.5, Oxford University Press) ⚡ Research Highlight - A bioluminescent reporter bioassay for in-process assessment of chimeric antigen receptor lentiviral vector potency
academic.oup.com/abt/article/... #bioluminescentreporterassay #CARLV

Antibody Therapeutics (IF=4.5, Oxford University Press)
⚡ Review Highlight - Structure and function of therapeutic antibodies approved by the US FDA in 2024.
academic.oup.com/abt/article/...
#bispecificantibodies #bsab #bsabs #FDA

Generation of antagonistic biparatopic anti-CD30 antibody from an agonistic antibody by precise epitope determination and utilization of structural characteristics of CD30 molecule Statement of Significance: Thirty-six bivalent biparatopic antibodies targeting pairs of nine distinct topographical epitopes distributed over CD30 were de

Antibody Therapeutics (IF=4.5, Oxford University Press)
🔥Research Highlight-Creating an antagonistic biparatopic anti-CD30 antibody from an agonistic one via epitope mapping and CD30 structural features
academic.oup.com/abt/article/...
#CD30EpitopeMapping #AntagonisticSignalingModulation

Antibody Therapeutics (IF=4.5, Oxford University Press)
🔹 Preventing Physical and Chemical Degradation of the LABL-fc-MOGR5, a Bifunctional Peptide Inhibitor, with Formulation Development Approaches.
academic.oup.com/abt/advance-...
#DrugFormulation #Biologics #ProteinStability #CMC

Analysis of the use of monoclonal antibodies in the treatment of Crohn’s disease Statement of Significance Despite clinical efficacy and safety, antibodies currently used for the treatment of Crohn’s disease have a number of limitations

Antibody Therapeutics (IF=4.5, Oxford University Press)
⚡ Review Highlight - Analysis of the use of monoclonal antibodies in the treatment of Crohn’s disease
academic.oup.com/abt/article/...
#Crohndisease #antibody #antibodytherapeutics #antibodydiscovery #antibodydevelopment

Antibody Therapeutics (IF=4.5, Oxford University Press)
⚡ Research Highlight - Application of a Novel LC-MS-Based Proteomic Workflow for Host Cell Protein Monitoring and Risk Control in Biotherapeutics
academic.oup.com/abt/advance-...
#antibody #LCMS #Biotherapeutics #HostCellProtein

Antibody Therapeutics (IF=4.5, Oxford University Press)
🔹 Affinity-optimized TROP2 antibodies support potent antitumor activity in antibody–drug conjugates
academic.oup.com/abt/advance-...
#ADC #TROP2 #CancerResearch #TargetedTherapy

Generation and characterization of novel high-affinity fully human antibodies targeting prostate-specific membrane antigen and prostatic acid phosphatase AbstractBackground. Prostate-specific membrane antigen (PSMA)-targeted therapies have revolutionized the management of patients with prostate cancer. Howev

Antibody Therapeutics (IF=4.5, Oxford University Press)
🚀 Generation and characterization of novel high-affinity fully human antibodies targeting prostate-specific membrane antigen and prostatic acid phosphatase
academic.oup.com/abt/article/...
#ProstateCancer #PSMA

Connexin 43 hemichannels and related diseases Statement of Significance: This article provides an overview of Connexin 43 hemichannels, elucidating their crucial involvement in various diseases and out

Antibody Therapeutics (IF=4.5, Oxford University Press)
🔥🔥Connexin 43 hemichannels and related diseases
academic.oup.com/abt/article/...
#Connexin43 #hemichannel #diseasestherapeutictargets

Bypassing the immunosuppressive effects of CA125/MUC16 via re-engineered rituximab (NAV-006) to improve its antitumor activity in vivo Statement of Significance: Multiple recent studies have highlighted the immunosuppressive impact of MUC16/CA125 on antibodies immune effector function incl

Antibody Therapeutics (IF=4.5, Oxford University Press)
🔥🔥 Bypassing the immunosuppressive effects of CA125/MUC16 via re-engineered rituximab (NAV-006) to improve its antitumor activity in vivo
academic.oup.com/abt/article/...
#ADCC #CDC #CD20 #MUC16 #CA125 #rituximab #CD16

Discovery of a common light chain bispecific antibody targeting PD-1 and PD-L1 by Hybridoma-to-Phage-to-Yeast (H2PtY) platform Statement of Significance: We discovered a common light chain (CLC) bispecific antibody targeting PD-1 and PD-L1 with favorable biophysical properties and

Antibody Therapeutics(IF=4.5, Oxford University Press)
🎯🎯Discovery of a common light chain bispecific antibody targeting PD-1 and PD-L1 by Hybridoma-to-Phage-to-Yeast (H2PtY) platform
academic.oup.com/abt/article/...
#PD1 #PDL1 #YeastDisplay #Hybridoma

The development of a next generation NK cell engager platform by integrating a potency-reduced IL-15 variant to enhance antitumor activity Statement of Significance Current NK cell engagers (NKCE) show limited clinical efficacy. We developed a novel tetravalent NKCE platform incorporating a re

Antibody Therapeutics(IF=4.5, Oxford University Press)
🚀🚀The development of a next generation NK cell engager platform by integrating a potency-reduced IL-15 variant to enhance antitumor activity
academic.oup.com/abt/article/...
#NKengager #IL15 #Antibody

Reforming solid tumor treatment: the emerging potential of smaller format antibody-drug conjugate Statement of Significance: The research on ADCs is advancing toward an innovative transitional phase. Small antibody fragments or other structurally derive

Antibody Therapeutics(IF=4.5, Oxford University Press)
🔥🔥Reforming solid tumor treatment: the emerging potential of smaller format antibody-drug conjugate
academic.oup.com/abt/article/...
#SolidTumor #ADC

Unique loop-structured CD19/CD22 bispecific CAR-T-cell therapy for patients with relapsed/refractory diffuse large B-cell lymphoma: an observational study Statement of SignificanceA unique loop structure-based CD19/CD22 bispecific chimeric antigen receptor (CAR) increases dual-targeting efficacy.The CD19/CD22

Antibody Therapeutics(IF=4.5, Oxford University Press)
Unique loop-structured CD19/CD22 bispecific CAR-T-cell therapy for patients with relapsed/refractory diffuse large B-cell lymphoma: an observational study
academic.oup.com/abt/article/...
#CD19 #CD22 #Bispecific #Antibody #CART

Overcoming antigen tolerance to develop GB22–45-2, an anti-DKK1 antibody for gastric cancer Statement of Significance This study presents GB22–45-2, a novel anti-DKK1 monoclonal antibody with comparable anti-tumor activity and better specificity t

Antibody Therapeutics(IF=4.5, Oxford University Press)
Overcoming antigen tolerance to develop GB22–45-2, an anti-DKK1 antibody for gastric cancer
academic.oup.com/abt/article/...
#Antibody #DKK1

Next generation of multispecific antibody engineering Statement of Significance: Multispecific antibodies hold immense potential in addressing unmet medical needs unachievable by monoclonal antibodies, yet the

Antibody Therapeutics(IF=4.5, Oxford University Press)
Next generation of multispecific antibody engineering
academic.oup.com/abt/article/...
#Antibody #Multispecific

IMM47, a humanized monoclonal antibody that targets CD24, exhibits exceptional anti-tumor efficacy by blocking the CD24/Siglec-10 interaction and can be used as monotherapy or in combination with anti... Statement of Significance: Novel humanized mAb MM47 has excellent anti-tumor efficacy by blocking CD24/Siglec-10 interaction with strong antibody-dependent

Antibody Therapeutics(IF=4.5, Oxford University Press)
🎇🎇IMM47, a humanized monoclonal antibody that targets CD24, exhibits exceptional anti-tumor efficacy by blocking the CD24/Siglec-10 interaction...
academic.oup.com/abt/article/...
#CD24 #Antibody

CAR NK cell therapy for solid tumors: potential and challenges Statement of Significance This review highlights the promise of CAR NK cell therapy as a safer, off-the-shelf alternative to CAR-T cells for solid tumors.

Antibody Therapeutics(IF=4.5, Oxford University Press)
🔥🔥CAR NK cell therapy for solid tumors: potential and challenges
academic.oup.com/abt/article/...
#CAR_NK #SolidTumor

Preclinical studies of BB-1701, a HER2-targeting eribulin-containing ADC with potent bystander effect and ICD activity Statement of Significance: A HER2-targeting eribulin-containing ADC had exhibited good plasma stability; BB-1701 had potent antitumor activities against mu

Antibody Therapeutics(IF=4.5, Oxford University Press)
📢📢Preclinical studies of BB-1701, a HER2-targeting eribulin-containing ADC with potent bystander effect and ICD activity
academic.oup.com/abt/article/...
#ADC #HER2 #Antibody

CAR NK cell therapy for solid tumors: potential and challenges Statement of Significance This review highlights the promise of CAR NK cell therapy as a safer, off-the-shelf alternative to CAR-T cells for solid tumors.

Antibody Therapeutics(IF=4.5, Oxford University Press)
🔥🔥CAR NK cell therapy for solid tumors: potential and challenges
academic.oup.com/abt/article/...
#CAR_NK #SolidTumor

GB12-09, a bispecific antibody targeting IL4Rα and IL31Rα for atopic dermatitis therapy Statement of Significance: This research highlighted a novel approach to atopic dermatitis therapy by employing bispecific antibody targeting IL4Rα and IL3

Antibody Therapeutics(IF=4.5, Oxford University Press)
🎯🎯GB12-09, a bispecific antibody targeting IL4Rα and IL31Rα for atopic dermatitis therapy
academic.oup.com/abt/article/...
#IL4Ra #IL31Ra #AtopicDermatitis #Antibody

Fc gamma receptors promote antibody-induced LILRB4 internalization and immune regulation of monocytic AML Statement of Significance: Receptor internalization mediated by the LILRB4 neutralizing antibody h128-3 is in part dependent on the IgG1-Fc interaction wit

Antibody Therapeutics(IF=4.5, Oxford University Press)
🚀🚀Fc gamma receptors promote antibody-induced LILRB4 internalization and immune regulation of monocytic AML
academic.oup.com/abt/article/...
#FcGammaReceptor #LILRB4 #AML

Antibody Therapeutics(IF=4.5, Oxford University Press)
🔥🔥Humanized anti-CD11d monoclonal antibodies suitable for basic research and therapeutic applications
academic.oup.com/abt/article/...
#CD11d #Antibody