Continuous-flow photochemistry for the efficient synthesis of 2,2,2-trifluoro-1-(3′-methoxy-[1,1′-biphenyl]-4-yl)ethan-1-ol Fine chemicals with fluorine atoms are vital for developing modern medicines and agrochemicals, but their synthesis can be hazardous and inefficient. We de

Khan et al. report visible-light Ni-catalysed flow synthesis of a key trifluoromethyl intermediate for tryptophan hydroxylase inhibitor, LX1031.
Flow photochemistry boosts scalability, efficiency, and practicality in synthesis. #AusJChem @csiropublishing.bsky.social
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A single stable topological stereoisomer of a two disulfide conotoxin mimetic demonstrates full potency on the human norepinephrine transporter One peptide, two topological stereoisoforms: cysteine-rich peptides are thought to have a defined number of folds depending on the number of cysteine resid

Latest research in #AusJChem!
Led by Alewood et al., explores a conotoxin-derived peptide targeting hNET for neuropathic pain. Discovery of topological stereoisomers highlights new structural complexity for peptide design and drug development. @csiropublishing.bsky.social

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Task-specific synthesis of novel indole-based porous organic polymers for carbon dioxide adsorption and iodine uptake This graphical abstract illustrates the dual adsorption capabilities of indole-based porous organic polymers (POPs). For CO2 capture, the POPs interact wit

They attribute the effectiveness of these polymers to their hierarchical pore structure and large number of active adsorption sites.

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A hydrophobic drag-reducing coating for a silicone rubber intestinal obstruction catheter A hydrophobic and drag-reducing coating was developed for silicone rubber intestinal catheters by a facile spray-coating method. The coating, based on an e

New in #AusJChem!
Li et al. show a hydrophobic drag-reducing coating for silicone rubber intestinal catheters. The EP/PDMS–nSiO₂–KH570 coating cuts friction (~77%), resists bacterial adhesion and could significantly improve patient comfort. @csiropublishing.bsky.social

doi.org/10.1071/CH25...

Nature-derived products and peptides: emerging insights into the mechanisms of visceral pain Naturally derived products that target ion channels and receptors have been crucial in revealing how pain from internal organs is sensed and regulated. The

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Metal-doped graphene as adsorbents for glyphosate: a DFT and molecular dynamics approach This study examines how glyphosate, one of the most widely used herbicides worldwide, interacts with graphene-based materials. Using computer simulations,

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Mojica-Sánchez et al. explore metal-doped graphene for glyphosate removal using DFT and molecular dynamics. Fe³⁺- and Al³⁺-doped graphene show the strongest adsorption, highlighting promising nanomaterials for environmental remediation. #AusJChem
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This article forms part of the 70th Birthday Tribute to Professor David Craik. @csiropublishing.bsky.social #AusJChem

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The C-terminal region of Opisthorchis viverrini granulin-1 promotes cell proliferation in the absence of regular secondary structure This study examined the folding of the C-terminal region of a liver fluke granulin and revealed distinct differences from the N-terminal region. Although t

A recent study by Daly et al. reveals that the C-terminal region of Opisthorchis viverrini granulin-1, despite lacking regular structure, still drives strong fibroblast growth, highlighting surprising bioactivity and potential as a wound-healing agent. #AusJChem

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This article is part of the 70th Birthday tribute to Professor David Craik. #AusJChem @csiropublishing.bsky.social

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Proline hydroxylation and C-terminal amidation in µ-conotoxins increase structural stability and potency at sodium channels Conotoxins serve as useful model peptides to understand the effects of protein posttranslational modifications (PTMs). Here, we focus on proline hydroxylat

Conibear et al. have published exciting new work uncovering how post-translational modifications shape the stability and activity of µ-conotoxins. A great step forward for peptide chemistry and ion-channel research. #AusJChem @csiropublishing.bsky.social
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NMR spectroscopy for mixture analysis – both a blessing and a curse: dissecting cell growth media as an example NMR spectroscopy helps analyse complex mixtures like cell culture media, revealing both expected and hidden components. It uncovered ethanol contamination,

(5/5) Access the research article here: doi.org/10.1071/CH25117

This article is part of the 70th Birthday tribute to Professor David Craik. The collection can be accessed here:
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Redox-active zwitterionic ZCp ligands for stable RhI/IrI complexes and hyperpolarisation applications This work reports stable RhI and IrI complexes supported by redox-active zwitterionic cyclopentadienyl ligands. The Ir complex shows reversible reduction a

New research in #AusJChem!
Lee et al show that zwitterionic cyclopentadienyl ligands can stabilise low-valent Rh(I)/Ir(I) complexes, revealing powerful redox behaviour and hyperpolarisation capability. A smart step forward for advanced catalysis. #AusJChem
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We’re proud to support opportunities that recognise outstanding research and presentation by #EarlyCareerChemists, and to continue championing Australia’s vibrant chemistry community through @ausjchem.bsky.social.

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Definition of important factors in polarised infrared spectroscopy: vibrational circular and linear dichroism in normal transmission mode and in attenuated total reflectance Vibrational linear dichroism (VLD) spectroscopy is an attractive technique to study oriented samples. This paper explores the theory required to understand

Rodger et al. explain the origin of vibrational linear dichroism (VLD) artefacts in transmission and attenuated total reflectance (ATR), improving how polarised IR data are interpreted for clearer structural insight. #AusJChem @csiropublishing.bsky.social
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Stabilisation of lipid membranes by β-peptide fibres Hydrogels are used to help tissues regenerate but need to be compatible with the cell surface. We have developed novel β-peptide hydrogels that can be deco

Aguilar et al unveil an AFM-based approach to study how β-peptide hydrogels interact with cell membranes. Using β-peptide fibres to support lipid bilayers (SLBs), they reveal nanoscale membrane behaviour, paving the way for smarter biomaterials. #AusJChem #openaccess
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New method for the preparation of ferrate(VI) (FeO42−) under acidic conditions The study described for the first time a new method for the synthesis of FeVI species under acidic conditions. Compared to alkaline methods, the advantages

Tianhui Wang & al. present the first synthesis method for ferrate(VI) (FeO42−) in acidic conditions. This is a more effective and greener method when compared to the typical alkaline synthesis method which can prove destructive and pollutive.

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Free energy relationship of substituent effects on nucleophilic substitution reactions of butyl methyl chlorophosphate with pyridines in acetonitrile The nucleophilic substitution reactions of butyl methyl chlorophosphate (3) with X-pyridines in MeCN at 35.0°C. A concerted mechanism is proposed based on

Hasi Rani Barai & al. present an optimised synthesis for butyl methyl chlorophosphite. They then investigated the kinetics of the compounds reaction with X-pyridines in order to propose a concerted mechanism for the nucleophilic substitution

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Evaluation of anticancer activity and mechanism studies of iridium(III) polypyridyl complexes toward SK-hep1 cells Three new IrIII complexes were synthesised and characterised. The in vitro anticancer activity of the complexes toward SK-hep1 cells was explored upon irra

Light-activated cancer therapy! Liu et al. show that iridium-based compounds remain inactive in the dark but, when exposed to light, generate reactive oxygen species that selectively kill cancer cells. #AusJChem @csiropublishing.bsky.social

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Ruthenium(II) complexes with 6,6′-disubstituted bipyridine ligands and their reactivity towards CO and H2 for homogeneous syngas conversion Bipyridine ligands with proximate H-bonding substituents in the 6,6′ positions have been used to prepare RuII complexes for potential application in the ho

New paper from the Britovsek et al!
Ru complexes with 6,6′-functionalised bipyridines stabilise low-valent Ru dimers and Ru-6 carbonyl clusters. These insights inform future ligand design for homogeneous syngas conversion and sustainable fuels. #AusJChem
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Ultrasound-assisted deep-eutectic-solvent-based dispersive liquid–liquid microextraction for lead detection in high-salt foods: a green analytical strategy for overcoming sodium chloride interference Lead contamination is prone to occur during the processing of high-salt foods. Conventional detection methods exhibit limited tolerance for high-salt matri

Graphite furnace atomic absorption spectroscopy (GFAAS) struggles to detect lead in salty foods. Xifeng Gao et al. present a new microextraction- based deep eutectic solvent GFASS method which is capable of overcoming NaCl matrix interference.

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Congrats to Prof Deanna D’Alessandro, #AusJChem Associate Editor, for being named one of Australia’s Top 250 Researchers!

A global leader in MOFs, materials chemistry, electrochemistry and carbon capture.

A truly well-deserved recognition!
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Specific chemical determinants are central for achieving ligands for selective detection of amyloid-β deposits in Alzheimer’s disease We show that chemical modifications of a thiophene moiety in ligand HS-276 can retain or disrupt its binding to Aβ deposits in Alzheimer’s disease. This fi

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Mousavi et al show that precise chemical features, especially the terminal heterocycle and flexible thiophene core, are essential for ligands to selectively detect amyloid-β deposits, guiding probes for Alzheimer’s diagnostics.
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Phase change microcapsules modified by thermal conductivity reinforced materials for enhanced thermal energy storage The n-octadecane reagent forms a stable water-in-oil emulsion with CNF. Formaldehyde reacts with melamine to produce melamine-formaldehyde resin prepolymer

Liu et al. show that incorporating alumina, silicon carbide and graphene into melamine formaldehyde resin boosts thermal conductivity and stability in phase-change microcapsules, offering strong potential for energy-efficient buildings and smart textiles.
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The potential of classical antibacterial peptides in mammalian antiviral chemotherapy The potential of classical antimicrobial peptides in anti-virus therapy is discussed in light of research spanning decades. Neither the in vitro activity n

Laszlo Otvos Jr reviews the research that has been done towards the applications of Classical antimicrobial peptides (AMPs) for use as anti-viral agents.

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Disulfide-rich peptides as next-generation radiopharmaceuticals Disulfide-rich peptides are ultra-stable biomolecules, making them excellent candidates for drug development. This article explores their potential as prec

This review by Conan K. Wang and colleagues highlights the current use and future directions of disulfide-rich peptides as next-generation radiopharmaceuticals in imaging & therapy.
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The potential of classical antibacterial peptides in mammalian antiviral chemotherapy The potential of classical antimicrobial peptides in anti-virus therapy is discussed in light of research spanning decades. Neither the in vitro activity n

Laszlo Otvos Jr reviews how classical antimicrobial peptides, long known for killing bacteria, may also inhibit viruses. Though their antiviral activity is weak, they provide valuable templates for designing next-generation antiviral peptide drugs.

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NMR spectroscopy for mixture analysis – both a blessing and a curse: dissecting cell growth media as an example NMR spectroscopy helps analyse complex mixtures like cell culture media, revealing both expected and hidden components. It uncovered ethanol contamination,

New in the press!

A study by Marx et al shows how NMR spectroscopy is both a blessing and a curse! This uncovered unexpected ethanol and hidden components in cell growth media, revealing unseen complexities that impact reproducibility.

#AusJChem #openaccess
Detail- connectsci.au/ch/article/7...

Effect of histidine on the antimicrobial peptide maculatin 1.1 solution-state NMR and molecular dynamics simulation structures at different protonation states The solution structure and topology of a pH-sensitive, histidine-rich analogue of the antimicrobial peptide maculatin 1.1 were investigated using circular

Sani and colleagues investigate the solution structure and topology of a pH-sensitive, histidine-rich analogue of the antimicrobial peptide maculatin 1.1 using circular dichroism, solution-state NMR spectroscopy and molecular dynamics simulations. #AusJChem

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Text invites us to read "The Foundations of a Nobel Prize: Richard Robson", a new collection in Australian Journal of Chemistry that is free to read until February 2026. The blurred background image of chemistry equipment is credited as being by AndreaObzerova, Getty Images Pro.

New #FreeToRead collection in @ausjchem.bsky.social:

Celebrating the work of #RichardRobson, a founding figure of Metal-Organic Frameworks and 2025 #NobelPrize in Chemistry recipient 🧪

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Shaping the future of constrained peptides and compact proteins in drug discovery Constrained peptides and compact proteins are exciting amino acid-based molecules with strong potential as new medicines. Smaller than antibodies, they can

A recent review by Ullrich et al highlights the advances in constrained peptides and compact proteins, showing how cyclic, stapled, and AI-designed miniproteins offer stability and precision for tough targets, shaping the future of drug discovery.
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