Additionally, other MedChemExpress reagents (e.g. #RSL3, #erastin, #ferrostatin1, #BODIPY #fluorescent dye) were used in lipid peroxidation and #ferroptosis-related assays, enabling precise evaluation of oxidative lipid damage and metabolic responses.
#MolecularBiology #Cancer #Oncology

🚨Our last paper in collaboration with the Federal Fluminense University in Niteroi, Brazil and the University of Aveiro in Portugal.
Using BF2 derivatives emitters to measure the temperature in doped polymeric films.
🔗https://doi.org/10.1016/j.dyepig.2025.113427
#BODIPY #Polymer #Temperature

This Friday is #EuropeanResearchersNight ⚗️🧪Come visit us and other research groups @TCD_Chemistry
in @tcdTBSI @TCD_Chemistry @tcddublin.bsky.social . Everyone is welcome 📢! Great science and fun people 👨‍🔬👩‍🔬😀#porphyrins #chlorophyll #cubane #BODIPY #PDT #bicyclopentane @researchireland.ie

A series of unsymmetrically substituted BODIPY dyes featuring fused benzo- or naphtho-fragments on one pyrrolic unit were synthesized from the corresponding pyrrolic precursors. The synthetic route was optimized using a modular approach based on the condensation of formylpyrroles with alkylpyrroles, enabling the identification of precursor combinations that minimize byproduct formation and improve preparative yields. The resulting benzo- and naphtho-fused BODIPYs display intense fluorescence in the red region, with emission maxima spanning 590–680 nm and fluorescence quantum yields ranging from 0.27 to 0.84. Their two-photon absorption (2PA) properties were studied both experimentally and computationally. An increase in the two-photon absorption cross-section with an increase in the size of the π-conjugated system was observed, reaching 80 GM for the naphthoBODIPY derivative. These findings demonstrate the potential of π-extended BODIPY scaffolds as NIR-active fluorophores with enhanced nonlinear optical properties.

Out in @JOC_OL
#JOC: Synthesis and Optical Properties of Unsymmetric Aromatically π-Extended #BODIPY. Great collaboration with #MikhailFilatov @TUDubChemBPharm
@TCD_Chemistry
😀 pubs.acs.org/doi/full/10.... plus #sciart cover picture 🎨. Funded by @researchireland.ie

Rhenium(I)-Based Tetranuclear Metallorectangles from Linear BODIPY and Bischelating Aminoquinonato Ligands: Anticancer Properties, Host–Guest Interactions, and Molecular Docking Studies pubs.acs.org/doi/10.1021/... Gupta, Sakthivel, Manimaran, & co-workers @InorgChem #rhenium #BODIPY

Dyad System of BOAHY-BODIPY Conjugates as Novel Photoswitchable Photosensitizers for Photodynamic Therapy Photodynamic therapy (PDT) offers minimally invasive and repeatable cancer treatment options. Despite advancements in photosensitizer (PS) design, the optical control of PS activation remains unexplor...

BOAHY-BODIPY system introduces optical control to photodynamic therapy through photoisomerization, advancing precision therapy.

Great contributions by JH & kostia!

#PDT #Photopharmacology #CancerResearch #BODIPY #photoisomerization

doi.org/10.1021/acs....

Chemical feature-based machine learning model for predicting photophysical properties of BODIPY compounds: density functional theory and quantitative structure–property relationship modeling - Journal... Context Boron-dipyrromethene (BODIPY) compounds have unique photophysical properties and have been applied in fluorescence imaging, sensing, optoelectronics, and beyond. In order to design effective B...

AlvaDesc has been used in "Chemical feature-based machine learning model for predicting photophysical properties of BODIPY compounds..." doi.org/10.1007/s008...

Check alvaDesc at: alvascience.com/alvadesc/

#moleculardescriptors #qsar #machinelearning #BODIPY #compchem