This research could pave the way for clinical trials, potentially transforming outcomes for melanoma patients who progress on current therapies 🙌🎉

#Onco404 #Cancer #Oncology #Melanoma #BRAF #BRAFV600 #TargetedTherapy #Immunotherapy

✅ The combo showed activity in preclinical models, including immunotherapy-resistant xenografts.
✅ Dual targeting led to tumor regression and prolonged survival in mice, offering hope for relapsed patients ➡️🌟

#Onco404 #Cancer #Oncology #Melanoma #BRAF #BRAFV600 #TargetedTherapy #Immunotherapy

✅ FAK inhibitors + avutometinib (RAF-MEK clamp) synergize to overcome adaptive resistance mechanisms.
✅ Transcriptomic analysis uncovered FAK pathway activation in resistant tumors, driving RhoA-FAK-AKT survival signals.

#Onco404 #Cancer #Oncology #Melanoma #BRAF #BRAFV600 #TargetedTherapy

A study from UCSD reveals a new combination therapy to overcome treatment resistance in BRAF V600E melanoma, a major issue in targeted and immune therapies 🧬💊

📍Key Findings👇

@cp-cancercell.bsky.social

#Onco404 #Cancer #Oncology #Melanoma #BRAF #BRAFV600