The expansion and contraction of organs is aided by the protein fibulin-1, highlighted here, in a microscopy image, around the basement membrane (the big oval) that surrounds the spermatheca and the oocyte (the cluster inside the membrane). Image credit: Adam Soh

How the stretchiness of #worms could point to treatments for human #KidneyDisease.
In PNAS Journal Club: www.pnas.org/post/journal...

#BasementMembrane #CElegans #fibulin1 #DevelopmentalBiology #KidneyDisease

How do individual proteins sculpt the epithelial basement membrane?
Our new study uncovers their role in network structure, nematic alignment & fractal patterns.
🔗 www.sciencedirect.com/science/arti...
#CellBiology #ECM #BasementMembrane

🧬 New paper alert! We used AFM PeakForce tapping to map the nanoscale topography of the basement membrane in Drosophila wing discs—revealing unexpected fiber-like and self-affine structures. #BasementMembrane #AFM
www.sciencedirect.com/science/arti...

Looking for #MaterialStiffness of #BasementMembrane across tissues?
Excellent literature resource here😆👇

The basement membrane as a structured surface – role in vascular health and disease

@claireleclech.bsky.social @jcellsci.bsky.social 2020
journals.biologists.com/jcs/article/...

Human #CNS (Brain Spinal cord) (both healthy & diseased) Capillary wall contains Collagen I/III fibrils in dilated space of #BasementMembrane splits

27 case (Neurological disorders) + 18 ctrl
4 day~49 y/o

IHC/TEM/Immuno-gold

#FreeNeuropatho 2025
www.uni-muenster.de/Ejournals/in...

Epithelial Folding Through Local Degradation of an Elastic Basement Membrane Plate Epithelia are flat tissues with a solid-like basement membrane attached to their basal surface. During embryonic development, epithelia need to undergo folding processes. While recent studies suggest....

#Epithelial #morphogenesis requires #folding. In our latest study, we elucidate how tissues can fold through #BasementMembrane degradation in the absence of tissue growth using #PlateTheory. Check it out under onlinelibrary.wiley.com/doi/full/10....

Global #CellVolume (not nuclear vol) Expansion drives collective invasion of #BreastCancerCell through #BasementMembrane

TRPV4- & Osmolality-dependent

Collective invasion doesn't need #Invadopodia

Ovijit Chaudhuri lab #NatureMaterials 2023
www.nature.com/articles/s41...