#BiddingerLab

The diabetes gene Tcf7l2 organizes gene expression in the liver and regulates amino acid metabolism Though Tcf7l2 harbors the strongest genetic association with diabetes identified thus far, how it promotes metabolic disease remains unclear. Our aim …

New Molecular Metabolism study from the Biddinger Lab finds diabetes gene TCF7L2 is crucial for hepatic zonation and glutamine metabolism. Liver-specific Tcf7l2 knockout mice exhibit metabolic reprogramming, and decreased glutamine in humans with the rs7903146 variant. #BiddingerLab
hsph.me/Tcf7l2