#BiochemSocTrans

ACE2 and TMPRSS2 levels in lungs, kidney, gastrointestinal (GI) tract, reproductive organs, and how individual sex affects the levels. Protein/mRNA levels are illustrated by a green-to-red color scale.

Find out how the co-localisation of ACE2 and TMPRSS2 in oral and airway epithelia may explain the primary route of SAS-CoV-2 infection in this #BiochemSocTrans mini-review by Marie Lykke Bach and Jensen. doi.org/10.1042/BST2... 🧪

Emerging tools and methods to study cell signalling mediated by branched ubiquitin chains Branched ubiquitin chains are complex molecular structures in which two or more ubiquitin moieties are attached to distinct lysine residues of a single ubiquitin molecule within a polyubiquitin chain....

Hot off the (Portland) press, @kulathu.bsky.social and I wrote a review on branched #ubiquitin and the tools and strategies out there for studying it. Some really cool stuff going on right now and I'm really excited to see where things go from here. #BiochemSocTrans portlandpress.com/biochemsoctr...

Structural studies of inter-subunit interactions within shelterin.

The 2024 recipient of the Biochemical Society's Colworth medal, Dr Thi Hoang Duong Nguyen, discusses the structural biology of shelterin and telomeric chromatin in this #BiochemSocTrans mini review 🧪
doi.org/10.1042/BST2...

AZGs: a new family of cytokinin transporters Cytokinins (CKs) are phytohormones structurally similar to purines that play important roles in various aspects of plant physiology and development. The local and long-distance distribution of CKs is ...

And finally, a brief piece reviewing and discussing how AZGs fit into the CK signaling scenario in #BiochemSocTrans. For more details, feel free to DM!

VoR: doi.org/10.1042/BST2...
AAM: drive.google.com/file/d/12occ...
@PPPublishing

The rationale for targeting the Hippo pathway in cancer therapy. Different strategies have been developed to target the Hippo pathway in cancer therapy. According to working mechanisms, these strategies can be classified into four categories: targeting YAP/TAZ, targeting upstream regulators of YAP/TAZ, targeting peripheral regulators, and targeting downstream effectors. Candidate drugs in each category are listed.

The Hippo pathway is frequently dysregulated in human cancers and represents an ideal therapeutic target. Find out about the advances in targeting the Hippo pathway for cancer treatment this #BiochemSocTrans mini-review from Zhu et al. 🧪
doi.org/10.1042/BST2...

As my first bsky post, I'm excited to share our recent new mini review on the "Age-dependent regenerative mechanisms in the brain" published in #BiochemSocTrans. Led by @giada_vanacore and with @JensBagerChris1's help. Great job team.

portlandpress.com/biochemsoctr...

Tools and techniques for quantitative glycoproteomic analysis Recent advances in mass spectrometry (MS)-based methods have significantly expanded the capabilities for quantitative glycoproteomics, enabling highly sensitive and accurate quantitation of glycosylat...

Tools and techniques for quantitative glycoproteomic analysis #BiochemSocTrans #MassSpec portlandpress.com/biochemsoctr...

Happy to share our #BiochemSocTrans review:
Elisa Oberbeckmann and I discuss how in vitro reconstitution studies have contributed to our understanding of genome organisation and reflect on possible future applications.

doi.org/10.1042/BST2...

And of course, thanks to the editorial staff of #BiochemSocTrans @PPPublishing - making the process relatively painless 👏👏