FDA starts review of Regeneron's drug for rare disease FOP Can Regeneron's drug for ultra-rare bone disease FOP pick up the baton from Ipsen's Sohonos, whose growth has stalled?

Patients in the #US with rare #bonedisease fibrodysplasia ossificans progressiva (#FOP) could have a second treatment option in a matter of months, if the FDA clears a just-filed marketing application for #Regeneron's garetosmab therapy.

pharmaphorum.com/news/fda-sta...

‘Lab-in-the-loop’ approach seeks to ensure targets are causally linked in bone health, immunology and metabolic disease.

longevity.technology/news/relatio...

#longevity #biotech #investment #osteoporosis #bonedisease #aging

NU25 - Day 2
'Inherited and acquired metabolic bone disease in early life'

Professor Nick Bishop, Professor of Paediatric Bone Disease
@sheffielduni.bsky.social

#bonedisease #paediatric #neonatal

Those formidable bony plates on an alligator's body seem to arise where skin fibers are under tension. Image credit: Science Source/Millard H. Sharp.

How #alligator armor could offer clues to #BoneDisease. In PNAS Journal Club: www.pnas.org/post/journal...

#osteoderm #reptiles #bone #DevelopmentalBiology

After a quick break, it's time for our plenary speaker. Prof Laoise McNamara, @uniofgalway.bsky.social‬ with her talk on 'Breaking Down #BoneDisease: Multidisciplinary Research into Mechanobiological Mechanisms of #Osteoporosis and #Cancer Metastasis' #Mechanobiology #insigneoSC25

Treatment of osteoporosis in the solid organ transplant recipient: an organ-based approach
@theendo.bsky.social
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#boneresearch #transplantation #bonedisease #medsky #openaccess

Celltrion's bone disease biosimilars get approval in US - Yes Punjab News Celltrion, a South Korean biopharmaceutical firm, received FDA approval for two new biosimilars, Stoboclo and Osenvelt, for bone disease treatment in the U.S. The company aims to expand its biosimilar...

Celltrion's bone disease biosimilars get approval in US
yespunjab.com?p=99313

#Celltrion #Biosimilars #BoneDisease #USApproval #PharmaNews #Healthcare #Biologics #MedicalBreakthrough #FDAApproval #Biotech #RheumatoidArthritis #Osteoporosis

Doctor got my X-rays back today. I asked him to lay it on me, and he said I'm neurotic to the bone, no doubt about it...

#bonedisease

Frontiers | Components of the Endocannabinoid System and ... Background: The endocannabinoid system (ECS) is involved ...

#BoneDisease #BoneHealing #CannabinoidScience

www.frontiersin.org/articles/10.3389/fphar.2...

#SharedFacts #MolecularReality #CellularReality

Frontiers | Components of the Endocannabinoid System and ... Background: The endocannabinoid system (ECS) is involved ...

#BoneDisease #BoneHealing #CannabinoidScience

www.frontiersin.org/articles/10.3389/fphar.2...

#SharedFacts #MolecularReality #CellularReality

Frontiers | Components of the Endocannabinoid System and ... Background: The endocannabinoid system (ECS) is involved ...

#BoneDisease #BoneHealing #CannabinoidScience

www.frontiersin.org/articles/10.3389/fphar.2...

#SharedFacts #MolecularReality #CellularReality

Frontiers | Components of the Endocannabinoid System and ... Background: The endocannabinoid system (ECS) is involved ...

#BoneDisease #BoneHealing #CannabinoidScience

www.frontiersin.org/articles/10.3389/fphar.2...

#SharedFacts #MolecularReality #CellularReality

Frontiers | Components of the Endocannabinoid System and ... Background: The endocannabinoid system (ECS) is involved ...

#BoneDisease #BoneHealing #CannabinoidScience

www.frontiersin.org/articles/10.3389/fphar.2...

#SharedFacts #MolecularReality #CellularReality

Frontiers | Components of the Endocannabinoid System and ... Background: The endocannabinoid system (ECS) is involved ...

#BoneDisease #BoneHealing #CannabinoidScience

www.frontiersin.org/articles/10.3389/fphar.2...

#SharedFacts #MolecularReality #CellularReality

A loss of host-derived MMP-7 promotes myeloma growth and osteolytic bone disease in vivo - Molecular Cancer Matrix metalloproteinases (MMPs) play a critical role in cancer pathogenesis, including tumor growth and osteolysis within the bone marrow microenvironment. However, the anti-tumor effects of MMPs are poorly understood, yet have significant implications for the therapeutic potential of targeting MMPs. Host derived MMP-7 has previously been shown to support the growth of bone metastatic breast and prostate cancer. In contrast and underscoring the complexity of MMP biology, here we identified a tumor-suppressive role for host MMP-7 in the progression of multiple myeloma in vivo. An increase in tumor burden and osteolytic bone disease was observed in myeloma-bearing MMP-7 deficient mice, as compared to wild-type controls. We observed that systemic MMP-7 activity was reduced in tumor-bearing mice and, in patients with multiple myeloma this reduced activity was concomitant with increased levels of the endogenous MMP inhibitor, tissue inhibitor of metalloproteinases-1 (TIMP-1). Our studies have identified an unexpected tumour-suppressive role for host-derived MMP-7 in myeloma bone disease in vivo, and highlight the importance of elucidating the effect of individual MMPs in a disease-specific context.

New paper: A loss of host-derived MMP-7 promotes #myeloma growth and osteolytic #bonedisease in vivo. #cancer

molecular-cancer.biomedcentral.com/articles/10.11…

The Role of the Microenvironment in Prostate Cancer-Associated Bone Disease Current Osteoporosis Reports - The bone is a common site for metastasis in patients with advanced prostate carcinoma, and provides a ‘fertile’ milieu which stimulates tumour growth and...

New paper: Role of the Microenvironment in #Prostate Cancer-Associated #BoneDisease by @DrClaireEd, Christina Turner

link.springer.com/article/10.100…