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New from the CAP-IT MGUS U54 Center @bcmhouston.bsky.social in Cancer Biomarkers:
The Polyclonal Plasma Cell (PolyPC) signature is a strong negative predictor of MGUS progression to multiple myeloma.
📖 doi.org/10.1177/1875...
#Myeloma #MGUS #CancerBiomarkers #Hematology #CAPITPublication

HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy - PubMed Clear cell renal cell carcinoma (ccRCC), despite having a low mutational burden, is considered immunogenic because it occasionally undergoes spontaneous regressions and often responds to immunotherapi...

New study in Cell: HIF upregulates endogenous retroviruses in clear cell kidney cancer, generating tumor-specific antigens. ERV-targeting T cells show promise for immunotherapy and HIF stabilizers may unlock similar responses in other tumors. #CAPITPublication
pubmed.ncbi.nlm.nih.gov/40023154/