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Posts by CAP-IT

Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT) The Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT) is a collaborative research network with the goal of discovering targeted agents to

Launched by the National Cancer Institute in 2021, Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT) aims to develop a network for collaborative research in precision cancer prevention and interception.
More info: t.ly/wlcI_ or ncicapit.org.

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CAP-IT Summit 2026: Advancing Cancer Prevention and Interception | NCI CAP-IT Explore highlights from the recent CAP-IT Summit 2026

Some highlights from the just-concluded #CAPITSummit 🎉
www.linkedin.com/posts/nci-ca...

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Back from the @ncicapit.org Summit! Honored to contribute to designing vaccines for cancer before it emerges. Advocates J. Ahlstrom @healthtreeorg.bsky.social, E. Krischner (Li-Fraumeni), & R. Dubin @aliveandkickn.bsky.social reminded us why this research matters #CancerPrevention #Lynchsyndrome

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Postdoctoral Associate Position-Project Description

Postdoctoral Associate Position-Project Description

Postdoc Opportunity in Neoepitope-based Cancer Immune Interception! Join our @ncicapit.org research at @weillcornell.bsky.social to link immunoprevention targets with preclinical cancer preventive interventions. Apply by emailing blanderadmin@med.cornell.edu. #Postdoc #immunology #cancervaccines

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Final call to register for the March 30 CAP-IT Summit!
forms.gle/19GKAY6ADTXs...

Don’t miss the opportunity to engage with leaders in cancer prevention and interception.

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📣Faculty recruitment - cancer interception researcher
at Fox Chase Cancer Center. See JD 👇

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Early Career Scientist Opportunity 2026 Annual Call for Nominations to Highlight Early Career Scientists Conducting Research within the Mission of the NCI Division of Cancer PreventionPurpose

Only a few spots remaining! This is a great opportunity for early stage investigators to showcase their work to a broad scientific community.

prevention.cancer.gov/funding-and-...

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At today’s Bioinformatics & Computational Biology #CAPITWGMeeting, WG Chair Dr. Alan Hutson of @roswellpark.bsky.social k provided working group updates, and Dr. Li Zhang of Fox Chase Cancer Center presented on “Bayesian Compositional Models for Analyzing Microbiome Data.”

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Program: Friday, February 20 Friday Program Details for AACR IO: Discovery and Innovation in Cancer Immunology: Revolutionizing Treatment through Immunotherapy

Dr. Yongfeng He, CAP-IT nvestigator in Dr. Vivek Mittal Lab at Weill Cornell Medicine, will present their vaccine research at the Major Symposium 5 " New Breakthroughs in TCR Engineering" at the AACR Immuno-Oncology Conference in Los Angeles.
🗓 Feb 20 | 9:30–11:00 AM PT
www.aacr.org/meeting/aacr...

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CIP-Net

🧬 CIP-Net Project Spotlight
UG3CA290454 is developing a preventive cancer vaccine for people with inherited BRCA1/2 mutations, using chimeric RNA-derived neoantigens to stop breast cancer before it forms.
👉Learn more on the CIP-Net website: www.nci-cipnet.org/en/members/u...

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NCI CAP-IT

Join us at the CAP-IT Summit on March 30, 2026! The event is open to the public.
ncicapit.org/en/cap-it-su...

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Registration for the NCI CAP-IT Annual Summit: March 30, 2026 The upcoming NCI CAP-IT Summit is set to convene a diverse mix of participants, including senior leaders, experts, and emerging talents such as junior investigators and trainees, all dedicated to the ...

Save the date! The #CAPITSummit is happening on March 30, 2026.
A full day of science, strategy, and community—bringing together researchers, clinicians, and advocates to advance cancer prevention and interception.
Register now and join us:
tinyurl.com/5c6snwyz

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Registration for the NCI CAP-IT Annual Summit: March 30, 2026 The upcoming NCI CAP-IT Summit is set to convene a diverse mix of participants, including senior leaders, experts, and emerging talents such as junior investigators and trainees, all dedicated to the ...

Save the date! The hashtag#CAPITSummit is happening on March 30, 2026.
A full day of science, strategy, and community - bringing together researchers, clinicians, and advocates to advance cancer prevention and interception.
Register now and join us:
tinyurl.com/5c6snwyz

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#CAPITSCMeeting

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Rewiring natural killer cells for next-generation cancer therapies Harnessing the cytotoxic potential of natural killer (NK) cells for cancer immunotherapy has proven challenging. In this issue of Cancer Cell, Biederstädt et al. and Nikolic et al. utilize genome-wide CRISPR screening to uncover novel regulators of NK cell function, paving the way for developing next-generation NK cell therapies.

Rewiring natural killer cells for next-generation cancer therapies

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At today’s #CAPIT Bioinformatics & Computational Biology WG meeting, Dr. Chi Zhang of University of Nebraska - Lincoln presented his work on AI-powered image feature extraction and data synthesis in pancreatic cancer.

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The latest CAP-IT Newsletter is out!
It features highlights and reports from the July 2025 CAP-IT Summit, along with updates on network progress:
indd.adobe.com/view/32541c2...

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NCI CAP-IT

New Tools and Resources from the NCI Data Sharing Hub , now added to the CAP-IT Shared Resources Catalog. Check it out and all NCI/NIH Shared resources at the link below:
ncicapit.org/en/resources...

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The amazing @ptorresayuso.bsky.social from #FoxChaseCancerCenter and #TempleUniversity presenting his exciting research at the @ncicapit.bsky.social summit

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a poster that says out of this world ALT: a poster that says out of this world

The 2025 Annual @ncicapit.bsky.social Summit is #Outofthisworld good!!! The plenary speaker #EvaSzabo, the keynote presentation by #RafiAhmed followed by AI guru #ChanghueiYang & #force ‘s #SueFredman & panelist for #EmergingTechnologies lead by the amazing #ShannonHughes were extraordinary!!!

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Don't wait - register now for the CAP-IT Virtual Annual Summit on July 24, 2025!
Open to the public with exciting talks on cancer prevention and interception.
🔗 Register: tinyurl.run/M3wsBV
ℹ️ Info: ncicapit.org
📧 CAP-IT@nih.gov
#CancerPrevention #NCICAPIT

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A multi-adjuvant personal neoantigen vaccine generates potent immunity in melanoma A personalized neoantigen peptide vaccine formulated with Montanide plus poly-ICLC and administered with local ipilimumab plus systemic nivolumab induces robust neoepitope-specific T cell responses an...

A personalized neoantigen vaccine + Montanide/poly-ICLC/ipilimumab reshapes the T cell landscape in melanoma patients:
- Strong CD8+ responses
- TCR repertoires expanded beyond anti–PD-1
- Vaccine-specific TILs identified post-treatment

www.cell.com/cell/abstrac...?
#Neoantigen #Melanoma #Tcells

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We have a great lineup of events this summer, we hope you can join us!

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Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

New in @cellcellpress.bsky.social : Exercise boosts immune checkpoint inhibitor (ICI) efficacy in #Melanoma via microbiota-derived formate, which enhances CD8⁺ T cell immunity through Nrf2 activation.

cell.com/cell/abstrac...
#Immunotherapy #Microbiome #CancerResearch

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EHA–EMN Evidence-Based Guidelines for diagnosis, treatment and follow-up of patients with multiple myeloma Nature Reviews Clinical Oncology, Published online: 07 July 2025; doi:10.1038/s41571-025-01041-xIn these Evidence-Based Guidelines, a multidisciplinary panel of experts from the European Hematology Association and the European Myeloma Network provide key treatment recommendations for patients with smouldering multiple myeloma, and newly diagnosed or relapsed and/or refractory multiple myeloma, addressing the use of established drugs and novel immunotherapies as well as the management of disease-specific and treatment-related complications and adverse events.

Now online!

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Cancer vaccines and the future of immunotherapy Vaccines have had a major impact on the control of infectious disease, most recently by helping to combat the COVID-19 pandemic. Prophylactic cancer vaccines have prevented several malignancies by pro...

New in @thelancet.com : A comprehensive review on cancer vaccines and their role in shaping the future of immunotherapy.
Read here:
www.thelancet.com/journals/lan...

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New @thelancet.com - Retifanlimab with carboplatin and paclitaxel for locally recurrent or metastatic squamous cell carcinoma of the anal canal (POD1UM-303/InterAACT-2): a global, phase 3 randomised controlled trial

www.thelancet.com/journals/lan...

#GastroSky #MedSky #OncSky

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HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy - PubMed Clear cell renal cell carcinoma (ccRCC), despite having a low mutational burden, is considered immunogenic because it occasionally undergoes spontaneous regressions and often responds to immunotherapi...

New study in Cell: HIF upregulates endogenous retroviruses in clear cell kidney cancer, generating tumor-specific antigens. ERV-targeting T cells show promise for immunotherapy and HIF stabilizers may unlock similar responses in other tumors. #CAPITPublication
pubmed.ncbi.nlm.nih.gov/40023154/

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Registration for the NCI CAP-IT Annual Summit: July 24, 2025 The upcoming NCI CAP-IT Summit is set to convene a diverse mix of participants, including senior leaders, experts, and emerging talents such as junior investigators and trainees, all dedicated to the ...

We’re excited to announce that the CAP-IT Virtual Annual Summit will be held on July 24, 2025!
Register here:
docs.google.com/forms/d/e/1F...

For more information, visit : ncicapit.org or email: CAP-IT@nih.gov #CancerPrevention #NCICAPIT

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