Emergence and spread of Hyalomma ticks and Crimean-Congo haemorrhagic fever in Europe: a systematic review - Parasites & Vectors Background Crimean-Congo haemorrhagic fever (CCHF) is a severe, often fatal zoonotic disease caused by the CCHF virus (CCHFV). It is primarily transmitted by Hyalomma ticks, which serve as both reservoir and vector. While these ticks are endemic to Asia, Africa, and parts of Europe, recent detection...

As Europe warms, #Hyalomma ticks carrying #CCHFV expand northward.


parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-...

The #CCHFVACIM project unites partners across Europe to boost vaccine development & preparedness.

#OneHealth #ERINHA

New Vector of the Month alert! #Hyalomma #lusitanicum, transmitting #Theileria #annulata, #Coxiella #burnetiid, and potentially Crimean–Congo hemorrhagic fever virus #CCHFV, authored by Julia González, María Sánchez, Ángeles Olmeda & Raphaëlle Métras. #wildlife

authors.elsevier.com/a/1lqj15Eb1x...

wonderful #EMVZ at Saint Raphaël ! 😎
Anupriya and Vincent presented two of our projects on #CCHFV 🦠

Nice place, nice atmosphere and very cool community ☀️🍷

Thanks to the organizers 😁

Tomorrow! 📽️ Live #Webinar - Vector-borne viruses: new data, new tools with #XpediteDiagnostics

💡Viruses in focus:
        New study reveals major gaps in #CCHFV detection
📅Wednesday 23rd July 2025, 2pm BST 

Register:🔗https://tinyurl.com/mshyn3yf

#genomes #genomics #diagnostics #DNA #microbiology

Evidence of Crimean–Congo Hemorrhagic Fever Virus in Livestock and Wildlife in Northeastern Portugal  Following the death of an 83-year-old man from the district of Bragança, in north-eastern Portugal due to Crimean–Congo hemorrhagic fever (CCHF), a serological survey was conducted to investigate domestic and wild ruminants. The survey included samples from cattle(n = 94), sheep(n = 30), goats(n = 4), and red deer(n = 10) collected within the affected region and neighboring areas where the human case was reported. CCHF antibodies were detected by ELISA in the serum of sheep, cattle and red deer, corresponding to seropositivity rates of 3.33%, 38.29%, and 60%, respectively, indicating significant exposure to the virus. Indirect immunofluorescence assays further validated the ELISA results.   Most of the positive cattle originate from farms located in the Guarda district, which are located close to the Spanish border. None of the goats was positive for CCHFV-antibodies and viral-RNA was not detected in any of the samples. CCHFV-RNA was also not detected in 15 ticks from Dermacentor and Rhipicephalus genera collected from vegetation or cattle, on one of the positive farms. Our findings suggest that CCHFV is actively circulating in northeastern Portugal. Reports of human cases of CCHF in Spain, particularly near the border with Portugal, are consistent with the detection of CCHFV-RNA in ticks feeding on domestic and wild animals in western Spain, highlighting the potential for cross-border transmission and suggesting an established circulation of CCHFV in the Iberian Peninsula.   Published (July 11, 2025) in Sci. Reports: https://doi.org/10.1038/s41598-025-10627-5 

The researchers found a higher than expected prevalence of seropositive samples, with 38% of the cattle samples positive for antibodies against CCHF virus. Levels in red deer were much higher (60%). The findings suggest that CCHFV may be actively circulating in the Iberian Peninsula #CCHFV

🦠 Join us on June 25 at 3:00 PM ET / 21:00 CET for a #GVN webinar with Dr. Ali Mirazimi on how Crimean-Congo hemorrhagic fever virus hijacks cells via the LDL receptor.

#Virology #Webinar #CCHFV #GlobalHealth

Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread Glycoprotein GP38-specific antibodies reduce viral dissemination and GP38-mediated vascular leak in Crimean-Congo hemorrhagic fever virus infection.

A great talk at GRC on tick-borne #CCHFV #pathogenesis. GP38, a secreted viral protein, drives vascular leak by disrupting the endothelial glycocalyx, similar to DENV NS1. Antibodies blocked leak and protected mice; => GP38 can be considered a viral Toxin; www.science.org/doi/10.1126/...

A replicating RNA vaccine confers protection against Crimean-Congo hemorrhagic fever in cynomolgus macaques Our data demonstrate that our repNP vaccine and NP-specific antibody can protect against CCHFV in non-human primates.

Just published! Here we report immunogenicity and efficacy of our replicon RNA vaccine against Crimean-Congo hemorrhagic fever in a cynomolgus macaque model of #CCHFV infection. Stay tuned as we advance this candidate in clinical trials.

www.thelancet.com/journals/ebi...

The burden of viral disease in many African countries is underreported. Here, using the latest #sequencing approaches, this much needed study has identified the viral aetiology in patients with #fever. Numerous (re) emerging #arboviruses of concern found; #CCHFV #YFV #RVFV #DENV

... even without neutralizing the virus itself.

🚀 Targeting GP38 could be a game-changer for vaccine and therapeutic development against #CCHFV, a priority pathogen with no approved treatments.

#CCHFV #Virology #EmergingViruses #VaccineResearch #InfectiousDiseases
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Crimean-Congo haemorrhagic fever virus screening among African individuals in Spain: Lessons to learn - PubMed This is the first serosurvey conducted in Spain to suggest possible active circulation of the virus in Africans. Our results suggest the need for more extensive clinical and epidemiological studies in...

What a despicable scope of this study! Although not mentioned in the text, you can read between the lines that immigrants could be considered the source of CCHFV for Spain! #CCHFV pubmed.ncbi.nlm.nih.gov/39921135/?ut...

and wonderful poster presented by @bboson.bsky.social another PI of the team, on his latest paper in Emery Microbes and Infections #CCHFV #viralassembly 😁✌️
@ciri-lyon.bsky.social

Fantastic presentation on #CCHFV and #ISGs by Vincent Legros, one of our PIs, this morning at the ViroDay of the CIRI! 🤩
@ciri-lyon.bsky.social

Hi everyone!
To start on 🦋, we will share what we did during this crazy year!! 🤩🎉

To start, our work on the receptor of #CCHFV 🦠: www.nature.com/articles/s41...

And related to that: our review on lipoproteins receptors used by viruses 🚪: www.jbc.org/article/S002...

(S+) Zecken und FSME-Risikogebiete: »Hyalomma läuft gezielt auf uns zu« Wenn Zecken stechen, können sie Krankheitserreger übertragen. Expertin Ute Mackenstedt spricht über Gebiete mit besonderer FSME-Gefahr und über die Risiken durch die einwandernde Gattung Hyalomma.

🕷️'Gefahr durch neue Zeckenarten: #Hyalomma läuft gezielt auf uns zu" - wenn #Zecken stechen, können sie Krankheitserreger (z.B. #CCHFV, #Rickettsia, #TBEV) übertragen.'
Interview von @ninaweber.bsky.social mit Prof. Ute Mackenstedt (Uni Hohenheim)
www.spiegel.de/gesundheit/z...