Speedy A governs non-homologous XY chromosome desynapsis as a unique prerequisite for XY loop-axis organization | The EMBO Journal imageimageIn mouse spermatocytes, the X and Y chromosomes undergo rapid non-homologous synapsis and desynapsis during early pachynema. This study reveals that X-Y desynapsis initiated by the atypical ...

Two new #CDK2 papers bringing me back to my PhD days (1/2):

www.embopress.org/doi/full/10....

More mechanistic studies of CDK2/Spy1 role in meiosis including impt SUN1 phos site. Still unclear if CDK2/Spy1 is most impt for scaffolding/localization or enzymatic activity, or, "por que no los dos?"

Minisyposium on "Degraders and Glues" at #AACR25 co-chaired by Rima Al-awar and me this Tuesday, April 29, 2:30 pm CDT:
Hear about new degraders and molecular glues targeting #ALK, #CDK2, #KRAS, #TEAD, #AuroraA and #IKZF2
@theaacr.bsky.social

www.abstractsonline.com/pp8/#!/20273...

Roswell Park-Led Team Proposes CDK2 Enzyme as New Target for Cancer Therapy A new study published in the journal Nature Communications, led by Agnieszka Witkiewicz, MD, and Erik Knudsen, PhD, of Roswell Park, highlights the therapeutic impact of CDK2 inhibitors as treatment f...

New research from our team highlights a potential new treatment approach for some #breastcancers.

By targeting the enzyme #CDK2, scientists hope to overcome resistance to common treatments for cancers including breast and #pancreaticcancer.

Learn more: www.roswellpark.org/newsroom/202...