Previously available with a 200-round capacity and now also available as the new DRV250.

Both versions feature force-feed technology and the AutoClear anti-jam system for consistent performance.

ORDER NOW!
www.paintball.shop/search/?quer...

#paintball #paintballshop #CRBN #DRV200 #DRV250

CRBN DRV Hopper!
Bisher 200 Kapazität. Jetzt auch als DRV 250 bestellbar.

Beide Versionen mit Force Feed und AutoClear Anti Jam. Inklusive Case und USB-C Kabel.

JETZT BESTELLEN!
www.paintball.de/suche/?query...

#paintball #paintballde #CRBN #DRV200 #DRV250 #Neuheit

Unlocking the hidden pocket on a billion‑dollar drug target For years, a protein inside our cells has quietly powered billions of dollars' worth of cancer drugs. Now a team of researchers have discovered that this workhorse protein, called cereblon, in additio...

Unlocking the hidden pocket on a billion dollar drug target | #DrugDiscovery #chemsky #TPD #CRBN

we hope you enjoyed this paper as much as we do! 😉😘

if you’re interested in working with an allosteric ligand, reach out to Prof. Woo 🫡 we’re more than happy to share 🙌🏼🩵✨ #thefutureisallostery #CRBN #TPD

Winter paintball has its own appeal, but cold, wet conditions and early darkness call for more prep.

The right companions are available now.
Only while supplies last!
www.paintball.shop/Winter__t225...

#Paintball #WinterPaintball #Outdoor #coldweather #planeteclipse #crbn #mechanix

The new CRBN Essentials are here!

Hoodies, Shirts, SC Shorts and the cutoff tank top offer lightweight materials, a clean look, and performance in every application.

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#paintball #paintballshop #crbn #crbnpaintball #paintballgear #paintballclothing

Die neuen CRBN Essentials sind da!

U.A. Hoodies, Shorts, Cutoff shirt bringen leichte Materialien, cleane Optik und Performance in jedem Einsatzbereich.

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#paintball #paintballde #crbn #crbnpaintball #paintballgear #paintballkleidung

The CRBN GRX & ProV2 – THE high-end mask for pros!
➥ Ultra-light: only 295 grams
➥ Flexible face guard for maximum bounces
➥ Innovative magnetic quick-change lens system
➥ Includes mask case

» Order now:
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#paintballshop #paintball #crbn #goggle #GRX #ProV2 #magfed

Die CRBN GRX & ProV2 – DIE High-End-Maske für Profis!
➥ Ultraleicht: nur 295 Gramm
➥ Flexibler Face Guard für maximale Bouncer
➥ Innovatives Schnellwechselsystem mit Magnet
➥ Inklusive Masken-Case
» Jetzt bestellen:
tinyurl.com/mscax8pu

#paintballde #paintball #crbn #Maske #GRX #ProV2 #propaintball

The brand-new CRBN DRV Loader is here!

➥ Highly precise Force-Control setting
➥ AutoClear Anti-Jam
➥ Response time of just 12 ms (~83 BPS).

Now available for €299.
🛒 Order here:
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#paintballshop #paintball #crbn #drv #loader #hopper
#brandnew #newarrivals

Site-resolved assessment of targeted protein degradation Moreno Ballesteros et al. introduce a site-resolved strategy combining genetic code expansion and bioorthogonal chemistry to evaluate how ligand binding sites influence targeted protein degradation. T...

❗ 📚💡Site-resolved assessment of targeted protein degradation

www.cell.com/cell-chemica...

#TPD #Targeted_Protein_Degradation #CRBN

Understanding the role of H-bonds in the stability of molecular glue-induced ternary complexes Protein-protein interaction (PPI) networks play a central role in many biological processes and thus the possibility of modulating them using small molecules offers several biomedical and biotechnolog...

📚💡Understanding the role of H-bonds in the stability of molecular glue-induced ternary complexes from Jordi Juárez Jiménez lab.

chemrxiv.org/engage/chemr...

#TPD #Targeted_Protein_Degradation #CRBN

Beyond the G-Loop: CRBN Molecular Glues Potently Target VAV1 via a Novel SH3 RT-Loop Degron This study reports the discovery and characterization of novel CRBN molecular glues that selectively induce the proteasomal degradation of the hematopoietic-specific signaling protein VAV1, a key targ...

❗ 📚💡 Another paper going outside cannonical G-loop degron:

Beyond the G-Loop: CRBN Molecular Glues Potently Target VAV1 via a Novel SH3 RT-Loop Degron

www.biorxiv.org/content/10.1...

#TPD #Targeted_Protein_Degradation #CRBN

In-Cell Approach to Evaluate E3 Ligases for Use in Targeted Protein Degradation A major challenge in evaluating the suitability of ∼700 known and putative E3 ligases for target protein degradation (TPD) is the lack of ligase-specific binders. Here, we use genetic code expansion (...

📚💡In-Cell Approach to Evaluate E3 Ligases for Use in Targeted Protein Degradation

pubs.acs.org/doi/10.1021/...

#TPD #Targeted_Protein_Degradation #CRBN

The contribution of cyclic imide stereoisomers on cereblon-dependent activity Thalidomide, lenalidomide, and their derivatives mimic glutarimide and aspartimide protein modifications that give rise to a motif recognized by the E3 ligase substrate adapter cereblon (CRBN). These ...

❗📚💡The contribution of cyclic imide stereoisomers on cereblon-dependent activity from Christina Woo

pubs.rsc.org/en/content/a...

#TPD #Targeted_Protein_Degradation #CRBN

Perks of purifying some CRBN-based degraders - a quick shine of the UV light and you’ll know where your compound is! #TPD #PROTAC #MolecularGlue #CRBN #ChemSky

Engineering and sculpturing a smaller easy-to-use CRBN for new drug discoveries

‘Easy to handle’ Cereblon – a new tool for drug discovery and molecular glue screening 👍

www.sciencedirect.com/science/arti...

Congrats to the Đikić lab and Merck KGaA, in collaboration with Enamine Ltd, the Nowak Lab, the Langer Lab and iBET 😀
#CRBN #TPD #PROTAC

Was great to contribute to this story together with
JanGerhartz Dominika Pienkowska Ina Dressel & Thomas Geiger from the lab. #CRBN #Interactome #GLUES
authors.elsevier.com/sd/article/S...
Animation credit PROXIDRUGs. Thanks for fantastic colaboration.