Inhibition of #CYP3A4 by #voriconazole
Voriconazole is potent inhibitor of CYP3A4. Tacrolimus is extensively metabolized by CYP3A4. When given together, voriconazole inhibits metabolism of tacrolimus, resulting in significantly ⬆️tacrolimus concentrations & ⬆️risk of nephrotoxicity & neurotoxicity.

【Research】
A double-humanized CYP3A4/PXR rat model was developed to better predict human drug–drug interactions.
This model holds promise for preclinical drug development pipelines.
Kobayashi et al 2025 PMID: 40721555
#CYP3A4 #PXR #HumanizedRat #Preclinical

【ラット研究紹介】CYP3A4とPXRをヒト化した「ダブルヒューマナイズドラット」薬物代謝や相互作用の予測に有用で、前臨床段階の創薬パイプラインへの応用に期待
Kobayashi et al 2025 PMID: 40721555
#創薬 #薬物動体 #CYP3A4 #PXR

Predictable Stereoselective and Chemoselective Hydroxylations and Epoxidations with P450 3A4 Enantioselective hydroxylation of one specific methylene in the presence of many similar groups is debatably the most challenging chemical transformation. Although chemists have recently made progress...

Throwback to 2011: our lab investigated stereo- and chemoselective oxidations with Cytochrome P450, using an inexpensive chemical auxiliary. #chemsky #CYP3A4
pubs.acs.org/doi/10.1021/...

Grapefruit tastes even better than I remembered. I nearly cried it was so good. #TamoxifenVacation #BCSM #CYP3A4 @thankscancer.bsky.social

Agrumes et médicaments : un cocktail parfois difficile à apprécier Pourquoi quelques agrumes, dont le pamplemousse, ne font-ils pas bon ménage avec certains médicaments ? Quels sont les dangers ? Quels sont les patients les

Every year in Nov/Dec when I start eating Clementines my tacrolimus (Prograf) trough levels "happen" to increase substantially (double..) if I've eaten a couple the day before the test. I'm convinced of #CYP3A4 link but I'm always told not.. any thoughts ?! www.vidal.fr/actualites/2... #nephsky

Why is everyone suddenly tweeting about the grapefruit juice effect? I was taught it in 1998. Has something changed? #CYP3A4