Graphical abstract illustrating single-cell isolation and labeling techniques linking cell phenotype to genotype. Methods such as robotic aspiration, laser detachment, microraft arrays, optical tweezers, droplet microfluidics, and spatial omics enable selective retrieval and molecular analysis of individual cells to study cancer heterogeneity.

📘 CHP Archive Spotlight #04
Review (2024) | Chen et al.
Linking phenotype ↔ genotype at single-cell resolution.
Reviews tools for isolating and profiling individual cells — key to understanding plasticity, metastasis & therapy resistance.
🔗 doi.org/10.47248/chp...
#SingleCell #CancerHeterogeneity

Graphical summary of SMLR1 in colorectal cancer liver metastasis. Primary colon tumor cells metastasize to the liver, where SMLR1 expression increases. SMLR1 interacts with macrophage receptors MRC1 (CD206) and SIGLEC1 (CD169), promoting macrophage polarization toward an immunosuppressive, pro-tumoral phenotype. The diagram highlights immune suppression and enhanced tumor growth within the liver-specific metastatic niche.

📖 Commentary Spotlight
In the inaugural issue, Liu discusses how SMLR1 reshapes the liver metastatic niche through macrophage polarization, highlighting its role in cancer plasticity and immune modulation.
🔗 www.pivotscipub.com/chp/1/1/0002...
#CancerHeterogeneity #TumorMicroenvironment

These speakers at #Pathobiology2026 will present cutting-edge applications that combine these tools, such as AI-guided spatial transcriptomic analysis to map clonal architecture, tumor-immune niches, and therapy-induced remodeling! pathobiology2026.asip.org

#AI #CancerHeterogeneity #ASIP2026

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By combining Live-seq with scRNA-seq, we empower researchers to directly measure cellular trajectories and unlock targeted therapies.
📖 Connect with Dr. @tobias-a-beyer.bsky.social, our CSO, to learn more! #CancerHeterogeneity #NGS #FluidFM