#CardiacScience

Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1α | Nature Cardiovascular Research Endurance exercise promotes adaptive growth and improved function of myocytes, which is supported by increased mitochondrial activity. In skeletal muscle, these benefits are in part transcriptionally coordinated by peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). The importance of PGC-1α to exercise-induced adaptations in the heart has been unclear. Here we show that deleting PGC-1α specifically in cardiomyocytes prevents the expected benefits from exercise training and instead leads to heart failure after just 6 weeks of training. Consistent with this, in humans, rare genetic variants in PPARGC1A, which encodes PGC-1α, are associated with increased risk of heart failure. In this model, we identify growth differentiation factor 15 (GDF15) as a key heart-secreted mediator that contributes to this dysfunction. Blocking cardiac Gdf15 expression improves cardiac performance and exercise capacity in these mice. Finally, in human heart tissue, lower cardiomyocyt

Endurance exercise boosts heart health via PGC-1α, suppressing GDF15. Without PGC-1α in heart cells, benefits drop! #CardiacScience PMID:40993371, Nat Cardiovasc Res 2025 @broadinstitute https://doi.org/10.1038/s44161-025-00712-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Heart has its own 'mini-brain' that controls its beat Scientists discovered that the heart contains its own nervous system, called a "mini-brain." This system controls the heartbeat independently.

Heart has its own ‘mini-brain’ that controls its beat: Scientists discovered that the heart contains its own nervous system, called a "mini-brain." This system controls the heartbeat independently.

#HeartMiniBrain #CardiacScience #Neuroscience #HeartHealth #HeartBeatControl #EarthDotCom

Cambridge Cardiovascular Seminar - Sodium-Glucose-coTransporter 2 inhibitors (SGLT2i): statins of the 21st century? Cardio-vascular protection through the Na+- interactome from Dr Coert Zuurbier

Interested in Cardiovascular Research then why not join us tomorrow for our last Seminar of 2024 @vpd-hlri.bsky.social.
Sodium-Glucose-coTransporter 2 inhibitors (SGLT2i): statins of the 21st century?
More info - bit.ly/3Apo4HI
#CardiovascularResearch #CardiacScience #Cardiology