#MedSky🧪#IDSky #Cellimmunity #publichealth #LongCOVID is recognized as a multifactorial disorder, with #Viralpersistent , discordant immunity, delayed #viralclearance & chronic inflammation. #Obesity has emerged as an independent risk factor for both #SARSCoV2 infection and its subsequent sequelaes
Environmental cues shape RTM development and tissue adaptation.
Distribution of long-lived RTMs across tissues and organs.
#MdSky🧪 #ImmunoSky #Cellimmunity Roles of Resident tissue macrophages (RTMs) in #innateImmunity beyond host defense
www.science.org/doi/10.1126/...
MedSky🧪#IDSky #Cellimmunity #Cellbiology @naturemedicine #Monocytes are the largest WBC ,they engulf and digest bacteria and cell debris. The activation of their RAGE ( the receptor for advanced glycation endproducts pathway in monocytes receptor) is correlated with a worse #COVID19 prognosis.
The figure illustrates the different types of tertiary lymphoid structures (TLS) found in tumors. TLS are defined as organized immune aggregates with distinct T and B cell zones, surrounded by peripheral node addressin (PNAd)-expressing high endothelial venules. (A) Immature or early TLS contain mature dendritic cell lysosomal associated membrane glycoprotein (DC-LAMP)+ dendritic cells (DCs) in the T cell zone. (B) Within mature TLS, primary follicle-like TLS have in addition T follicular helper (Tfh) cells and CD21+ follicular dendritic cells (FDCs) network allowing T cell immunity activation and low-affinity antibody production. (C) Secondary follicle-like TLS are characterized by the presence of a germinal center (GC) with B cell lymphoma 6 (BCL6) positive GC B cells, CD21+CD23+ FDC allowing the production of memory B cells and high-affinity antibody secreting plasma cells. Boxes indicate their potential impact on cancer control and on clinical outcome. TCF1, T cell factor 1. Create
#MedSky🧪 #cancerresearch #CellImmunity @cellpress The generation of anti-#tumorimmunity in the draining #lymphnodes is known as ‘the cancer immunity cycle’. Accumulating evidence supports the occurrence of such a cycle at tumor sites in the context of #chronicinflammation.
