Unmasking aryl thianthrenium salts in cells - Nature Synthesis Nature Synthesis - Unmasking aryl thianthrenium salts in cells

🎭 𝗨𝗻𝗺𝗮𝘀𝗸𝗶𝗻𝗴 𝗮𝗿𝘆𝗹 𝘁𝗵𝗶𝗮𝗻𝘁𝗵𝗿𝗲𝗻𝗶𝘂𝗺 𝘀𝗮𝗹𝘁𝘀 𝗶𝗻 𝗰𝗲𝗹𝗹𝘀: #CiQUS MetBioCat work recently highlighted by Nature Synthesis!

👉 doi.org/10.1038/s441...

The study, published in JACS, presents an unconventional strategy to uncage drugs in live settings, based on photoredox unmasking of aromatic C–H bonds.

Una estrategia sintética híbrida permite crear arquitecturas moleculares hasta ahora inalcanzables El diseño de materiales a escala molecular es una de las grandes apuestas de la ciencia actual. Moléculas orgánicas planas y altamente conjugadas se utilizan ya en tecnologías avanzadas como sensores

🪡 Un trabajo liderado desde el #CiQUS por Luis M. Mateo y Diego Peña ha desarrollado una estrategia sintética híbrida que combina química en disolución y reacciones sobre superficies metálicas para crear arquitecturas moleculares inéditas.

🔗 www.usc.es/ciqus/es/not...

#FondosEuropeos #RedeCIGUS

🫶 Many thanks to Dr. Martha E. Sommer (ISAR Bioscience GmbH) for her insightful Lecture yesterday at #CiQUS.

Such an engaging discussion, we appreciate your visit and the opportunity to learn from your expertise!

#RedeCIGUS #FondosEuropeos

Mauro Mato y Eva Rivera: «Para tener una carrera de investigador independiente en España te tienes que ir al extranjero» Ambos jóvenes, de 33 y 32 años, se graduaron en Química y no dudaron en seguir por la vía científica. Ahora trabajan en el Centro de Investigación en Química Biológica y Materiales Moleculares de la U...

#CiQUSintheMedia | 📰 La Voz de Galicia

Mauro Mato e Eva Rivera, investigadores do #CiQUS, comparten a súa experiencia e os desafíos de facer carreira científica en España.

🔗 www.lavozdegalicia.es/noticia/yes/...

#FondosEuropeos #RedeCIGUS

A investigadora do #CiQUS tamén detalla como exploran sistemas policíclicos non convencionais para estudar a aromaticidade, un concepto clave na química, e colaboran con astrofísicos para investigar a presenza destes compostos no espazo interestelar.

📽️ youtu.be/mCvHey2dbGo?...

O #CiQUS logra 5️⃣ proxectos na convocatoria 2025 das 𝗠𝗮𝗿𝗶𝗲 𝗦𝗸ł𝗼𝗱𝗼𝘄𝘀𝗸𝗮-𝗖𝘂𝗿𝗶𝗲 𝗣𝗼𝘀𝘁𝗱𝗼𝗰𝘁𝗼𝗿𝗮𝗹 𝗙𝗲𝗹𝗹𝗼𝘄𝘀𝗵𝗶𝗽𝘀, nunha edición de máxima competencia europea !

A @usc.gal obtén 8 axudas en total, terceira universidade do Estado en axudas MSCA-PF 👏

🔗 www.usc.es/ciqus/gl/nov...

#FondosEuropeos #RedeCIGUS

Photoredox Unmasking of Aromatic C–H Bonds in Living Environments Enabled by Thianthrenium Salts Prodrug strategies traditionally rely on masking polar functional groups of bioactive molecules with protecting units that can be removed by specific stimuli in biological settings. Here, we introduce an alternative uncaging approach that bypasses the need for heteroatom handles, based on reversible masking of aromatic C–H bonds with thianthrenium groups. Unmasking is triggered by low-energy photoredox activation, which generates aryl radicals that are rapidly reduced by endogenous bioreductants to restore the native C–H bond. Beyond establishing the feasibility of photoredox radical chemistry in living cells, we demonstrate a proof-of-concept application of this strategy for the modulation of activity of antifungal agents.

#CiQUS researchers have just published a JACS communication reporting an unconventional strategy to uncage drugs in live settings, based on a photoredox unmasking of aromatic C–H bonds

Congratulations to the authors on this outstanding work!

pubs.acs.org/doi/10.1021/...

#FondosEuropeos #RedeCIGUS

🧑🏽‍🔬👩🏻‍🔬 Esta semana temos visitas moi especiais: Estudantes de bacharelato de distintos puntos de Galicia están a coñecer estes días o noso centro e a investigación que facemos no #CiQUS.

Dámoslles a benvida e esperamos que lles guste a experiencia! ⚗️

#FondosEuropeos #RedeCIGUS

📢 𝗖𝗶𝗤𝗨𝗦 𝗦𝘂𝗺𝗺𝗲𝗿 𝗙𝗲𝗹𝗹𝗼𝘄𝘀𝗵𝗶𝗽𝘀 2026 are now open!

Are you a Bachelor’s student in Chemistry or related fields? Spend July 2026 at #CiQUS, gaining hands-on experience in cutting-edge research. Work alongside our teams, learn advanced techniques, and attend scientific seminars.

Polyimide‐Linked Hexaazatriphenylene‐Based Porous Organic Polymer with Multiple Redox‐Active Sites as a High‐Capacity Organic Cathode for Lithium‐Ion Batteries A high-capacity polyimide-linked porous organic polymer (HAT-PTO) incorporating numerous redox-active centers is synthesized via a hydrothermal reaction, delivering a high theoretical capacity of 484...

A investigación, publicada en 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘥 𝘔𝘢𝘵𝘦𝘳𝘪𝘢𝘭𝘴 contou coa participación de Jonathan Caroni, Arindam Mal e Rafael Ramos. Un recoñecemento ao traballo do equipo e á investigación que se desenvolve no #CiQUS 🔬👏

📖 doi.org/10.1002/adma...

O CiQUS obtén un novo proxecto Proof of Concept do ERC centrado no almacenamento enerxético sostible | Universidade de Santiago de Compostela O Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares da USC (CiQUS) acaba de obter un novo proxecto Proof of Concept (PoC) do Consello Europeo de Investigación (ERC), o quin...

Fantastic news! Our second #ERC #ProofOfConcept ZEST is underway at #CiQUS #Oportunius 🚀 More info: www.usc.gal/gl/xornal/no...

New ERC Proof of Concept for CiQUS: ZEST, an Innovative Solution for Sustainable Energy Storage The Center for Research in Biological Chemistry and Molecular Materials (CiQUS) at the University of Santiago de Compostela (USC) has secured a new Proof of Concept (PoC) grant from the European

🆕 Some more good news at #CiQUS! María Giménez López, Oportunius Researcher at CiQUS, has been awarded an ERC Proof of Concept' grant #ERCPoC.

ZEST project: Advanced Zn||Br₂-MnO₂ Batteries Enabled by Nanostructured Cathodes and Supramolecular Electrolytes

#FondosEuropeos #RedeCIGUS

Researchers from #CiQUS, IBM Research - Zurich, and Chalmers University of Technology used the tip of an atomic force microscope to selectively delete an oxygen atom from a single organic molecule, transforming a seven-membered ring into a six-membered ring embedded into a perylene skeleton.

Un traballo do #CiQUS sobre cátodos orgánicos de alta densidade enerxética, premiado pola Fundación Barrié e a RAGC.

#FondosEuropeos #RedeCIGUS

A investigadora do CiQUS María Giménez logra un proxecto Ignicia para impulsar novas baterías baseadas en zinc máis sostibles O despliegue das enerxías renovables e a modernización das redes eléctricas están a incrementar de forma notable a demanda de sistemas de almacenamento fiables, duradeiros e sostibles. Non obstante,

🔋 María Giménez logra un proxecto Ignicia para impulsar novas baterías baseadas en zinc máis sostibles

O programa #𝗜𝗴𝗻𝗶𝗰𝗶𝗮 Proba de Concepto da Xunta de Galicia apoiará con unha inversión estimada de 500.000 euros o proxecto 𝗭𝗶𝗻𝗖𝗔𝗚𝗘, liderado pola investigadora #Oportunius do #CiQUS.

🔬 Be a #CiQUSMaker! 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗜𝗻𝗶𝘁𝗶𝗮𝘁𝗶𝗼𝗻 𝗖𝗼𝗻𝘁𝗿𝗮𝗰𝘁𝘀

Are you a Master's student aiming for a doctoral thesis? Take your first step with us. #CiQUS offers part-time research contracts for professional research practice within our strategic and cooperative research lines.

#FondosEuropeos #RedeCIGUS

Química sostible dende o CiQUS: como será a enerxía do futuro? A investigadora María Giménez López desenvolve materiais híbridos e baterías para un almacenamento eficiente e respectuoso co medio

⚡️A enerxía sostible do futuro no #CiQUS co desarrollo de baterías zinc-aire, “unha das alternativas máis sostibles”, con materiais abundantes

🔋 O noso obxectivo: deseñar tecnoloxías para que a enerxía “se produce, almacena e consume de forma sostible, segura e accesible”

#FondosEuropeos #RedeCIGUS

Como vivir a ciencia co programa de mobilidade do CiQUS: "É unha experiencia inesquecible" As axudas do centro xa beneficiaron a máis de 40 investigadores e permiten realizar estadías en laboratorios de toda Europa

🌍 Como vivir a ciencia co programa de mobilidade do #CiQUS: "É unha experiencia inesquecible".

As axudas do centro xa beneficiaron a máis de 40 investigadores e permiten realizar estadías en laboratorios de toda Europa e abrir novas liñas de investigación.

#RedeCIGUS #FondosEuropeos

@gciencia.bsky.social profundiza no programa de mobilidade internacional do #CiQUS, unhas axudas que impulsan o desenvolvemento profesional dos #CiQUSmakers, fortalecen a rede de colaboradores e proxectan o labor científico do centro fóra das nosas fronteiras.

#RedeCIGUS #FondosEuropeos

Targeting the adenosinergic axis in cancer immunotherapy: Insights into A2A and A2B receptors and novel clinical combination strategies The extracellular accumulation of adenosine is a central mechanism of immune evasion within the tumor microenvironment. Elevated adenosine levels—driven by hypoxia, chronic inflammation, and upregulat...

Researchers from the Eddy Sotelo Lab at #CiQUS have published a comprehensive analysis in 𝘗𝘩𝘢𝘳𝘮𝘢𝘤𝘰𝘭𝘰𝘨𝘪𝘤𝘢𝘭 𝘙𝘦𝘷𝘪𝘦𝘸𝘴 on targeting the adenosinergic axis in cancer immunotherapy.

👉 Read the full review here:
pharmrev.aspetjournals.org/article/S003...

#FondosEuropeos #RedeCIGUS

Many thanks to Prof. Vincent Moliner for his inspiring talk at #CiQUS!

It was a pleasure to host you and explore innovative approaches to enzyme design and polymer recycling.

#RedeCIGUS #FondosEuropeos

A Rede CIGUS logra un novo fito para a I+G+i ao captar un proxecto de 11 M€ que permitirá contratar a 40 investigadores posdoutorais - Xunta de Galicia

🌐 A #RedeCIGUS, á que pertence o #CiQUS, acaba de lograr a concesión do seu primeiro proxecto europeo MSCA COFUND, denominado TALENTGAL.

Cun orzamento de máis de 11 M€, permitirá a contratación de 40 investigadores posdoutorais durante os próximos 5 anos nos centros da rede.

#FondosEuropeos

A work that paves the way for smart functional materials.

Led by Prof. Juan R. Granja & Prof. Javier Montenegro at #CiQUS.

Read more: doi.org/10.1002/anie...

Hoy, durante el Simposio de Investigadores Jóvenes en Zaragoza, Manuel Souto Salom, investigador del #CiQUS, ha recibido el Premio Joven Investigador que le fue otorgado por la Real Sociedad Española de Química (RSEQ) este año en la modalidad 𝘓𝘪𝘥𝘦𝘳 𝘥𝘦 𝘎𝘳𝘶𝘱𝘰.

#RedeCIGUS #FondosEuropeos

Novel antimicrobial self-assembled cyclic peptide nanotubes containing (1R,3S,4R,5R)-3-amino-4,5-dihydroxycyclohexane-1-carboxylic acid, a new building block for developing mimetics of saccharide–pept... A new class of supramolecular antimicrobials based on d,l-cyclic peptides containing a dihydroxylated-γ-residue, which was designed to mimic the saccharide component present in certain carbohydrate–pe...

#OpenAccess article by Juan R. Granja 𝘦𝘵 𝘢𝘭.
#CiQUS #USC

A new class of supramolecular #antimicrobials from D,L-cyclic #peptides with a dihydroxylated-γ-residue mimicking saccharides is described.

🔗 doi.org/10.1039/D5QO01374G

A delegation from Central South University (CSU, China) led by Vice President Li Zhihong visited #CiQUS this week.

The meeting provided an excellent opportunity to explore institutional collaboration and discuss future exchanges of students and researchers.

#FondosEuropeos #RedeCIGUS

International Research Team Awarded €10 Million ERC Synergy Grant to Revolutionize Drug Delivery A team of four leading scientists from four European universities has been awarded a prestigious Synergy Grant of approximately €10 million by the European Research Council (ERC) for the project

New #ERCSyG: Major news from #CiQUS! 🎉 Our researcher Javier Montenegro will serve as the corresponding principal investigator for the CARAMEL project, awarded a prestigious €10 million Synergy Grant from the ERC.

👉 Find out all the details on our website:

www.usc.es/ciqus/en/new...

👏 Many thanks to Dr. Igor Rončević from the University of Manchester for the inspiring talk on the electronic structure and coherence in π-conjugated systems. It was a real pleasure to host you at #CiQUS and exchange ideas on molecular nanostructures and aromaticity.

#SomosCIGUS #FondosEuropeos

A collaboration between Chalmers University of Technology , IBM Research Zurich, University of Manchester and #CiQUS reports in JACS the synthesis of the π-extended Clar’s goblet —a rare nanographene with four unpaired electrons and intriguing magnetic behaviour.

🔗 pubs.acs.org/doi/10.1021/...

Many thanks to Dr. Andrew Kellett for his visit to #CiQUS and for sharing his latest research on “Recent Advances in Artificial Gene-Editing and DNA-Targeted Metallodrug Design.” It was a real pleasure to host you and learn from your insightful talk.

#RedeCIGUS #FondosEuropeos