UPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironment - Cell Death & Disease Cell Death & Disease - UPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironment

What if we’ve been aiming at the wrong surface?

Under <0.1% O₂, UPR drives intracellular C5aR1 that supports tumour cell survival — favouring cell-permeable inhibitors. #GelCount used to track 3D spheroid growth and to image/analyze clonogenic plates.

#Hypoxia #Spheroids #ClonogenicAssay