U01.01.081 Vitamin B12 Test your knowledge of Vitamin B12. Practice identifying the causes of B12 deficiency—from veganism to Diphyllobothrium latum—and master the laboratory findings of elevated Methylmalonic Acid (MMA) and Homocysteine.

🧬 The Cobalt Core: Mastering Vitamin B12 (Cobalamin)! 🧬
#USMLEStep1 #MedEd #MedicalStudent #Biochemistry #VitaminB12 #Cobalamin #Step1Prep #HighYield #MedSchool #Hematology #Neurology #PerniciousAnemia #USMLE #FutureDoctor #StudyGram #MedTwitter

Vitamin B12: Was Du wissen solltest (für Deinen Alltag & Deine Gesundheit) 👉 hasenapotheke.de/vitamin-b12-... #VitaminB12 #Cobalamin

Is Cobalt Joining the σ-/π-Hole Crown? Exploring Noncovalent Interactions in Cobalamin Herein, the σ-/π-hole chemistry of Co within a biological framework was computationally studied for the first time using Cobalamin (Cbl) as a case study. Starting with a Protein Data Bank (PDB) survey, 111 structures involving Cbl were found, 67 of which presented a noncovalent interaction (NCI) involving the Co atom and either substrate/product molecules, protein residues, or artificial ligands. These data were statistically analyzed to unveil trends regarding the abundance and structural features of the L···Co interaction (L = C, N, and O), and several selected examples were investigated at the BP86-D3/def2-TZVP level of theory. In addition, a computational study revealed the existence of a σ-hole complex involving the 5,6-dimethylbenzimidazole (DMB) group as a stabilizing prestate prior to Co coordination. This finding was further assessed by the identification of several local noncovalent energy minima based on σ-hole interactions using NCH, NH3, OCHNH2, and O(CH3)2 as electron donor molecules, which were characterized using quantum chemistry tools. We believe that the results reported herein will have a significant impact on the fields of chemical biology, supramolecular chemistry, and biotechnology by describing for the first time σ-/π-hole interactions involving Co in biological systems, which are often overlooked by traditional coordination chemistry.

🔵 New paper alert!

A huge thank you to the authors Sergi Burguera and
Antonio Bauzá.

📄 DOI: doi.org/10.1021/jacs...

🔬 Highly recommended for those working in noncovalent interactions, bioinorganic chemistry, and theoretical modeling.

#NonCovalentInteractions #Cobalamin
@uib.cat @pubs.acs.org

Prevalence of Cobalamin (Vitamin B12) Deficiency Associated ... : Medical Journal of Babylon obalamin (vitamin B12) deficiency, particularly its gender-specific prevalence. Additionally, the study examined gastrin levels and antinuclear antibody positivity in patients diagnosed with AG. Mate...

Deficiencia de cobalamina es mayor en las mujeres que sufren gastritis autoinmune, así como la presencia de anticuerpos antinucleares #cobalamin #gastritis journals.lww.com/mjby/fulltex...

Comammox Nitrospira act as key bacteria in weakly acidic soil via potential cobalamin sharing Comammox Nitrospira are the dominant ammonia oxidizers in weakly acidic soil. They are the K-strategy species in weakly acidic soil and may promote bacterial cooperation under low pH conditions via c....

Comammox Nitrospira act as key #bacteria in weakly acidic #soil via potential #cobalamin sharing
onlinelibrary.wiley.com/doi/full/10....
#microbiome #SoilHealth #ecology

These Poseidoniales viruses encoded a unique functional repertoire of genes. Aside from virion morphogenesis, and genome packaging and replication, and AMGs such as #biotin synthesis, #cobalamin productio and metallophosphoesterase, amidoligase, glutamine amidotransferase (GATase) among others.