Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay Zhang et al. identify a regulatory mechanism for how cells adapt to nutrient scarcity through widespread −1 ribosomal frameshifts, culminating in accelerated mRNA decay. This process, dependent on cod...

#mRNADecay #Ribosome #Frameshift #Scerevisiae #NMD #CodonOptimality
Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay: Molecular Cell www.cell.com/molecular-ce...