A novel Coxsackievirus B5 vaccine candidate selected via biological properties shows promise for safer immunization.
doi.org/10.15212/ZOO...
#Coxsackievirus #Enterovirus #Vaccines #VaccineDevelopment

Happy Thanksgiving to all who celebrate! This #JEM_Spotlight highlights a study by George Fu Gao et al. that provides insight into how #Coxsackievirus, a common cause of childhood hand-foot-and-mouth disease (#HFMD), induces #onychomadesis (nail shedding).
doi.org/10.1084/jem....

#coxsackievirus B implicated in the disease.
The virus does not cause cancer directly but accelerates the development of pancreatic ductal adenocarcinoma (PDAC) in individuals with existing genetic mutations, specifically in the KRAS gene.

This suggests that preventing CVB infection could be an efficient strategy to block PDAC from occurring. An effective vaccination strategy to prevent #coxsackievirus B3 (CVB3)-induced #pancreaticcancer would require targeting not only CVB3 but also the other 5 serotypes of

Initial #Coxsackievirus B4 IgM titers were 1:80 & coxsackievirus B5 IgM titers were 1:40
1 week later: coxsackievirus B4 IgM>1:640 & coxsackievirus B5 IgM 1:80 establishing diagnosis of #viral #myositis

The crystal structures of the 3C proteases from Coxsackievirus B3 and B4 will guide the design of 3C-targeting inhibitors with broad-spectrum properties #Coxsackievirus #CVB3 #CVB4 t.co/0bmNbUuDAq