DCTPP1 May Be Promising Target for MNGIE, mtDNA Depletion Syndrome Similar to TK2d DCTPP1 modulates dNTP pool balance, which is disrupted in TK2d and related syndromes, and shows promise as a therapeutic target in MNGIE.

Findings of a recent study published in Cell Death & Disease suggest deoxycytidine triphosphate pyrophosphatase 1 (#DCTPP1) is a key regulator of mitochondrial nucleotide homeostasis.

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