Study Finds Link Between Deoxyguanosine Kinase Deficiency and Immune Activation in Liver Research shows DGUOK deficiency, a mitochondrial disorder like TK2d, reprograms hepatocellular metabolism and triggers innate immune signaling in the liver.

#DGUOK, a mitochondrial disorder similar to #TK2d, reprograms hepatocellular metabolism and triggers innate immune signaling through a purine-dependent mechanism, leading to metabolic and immunological changes. Study in @biorxivpreprint.bsky.social

Read more: https://bit.ly/3MwjLjG