#Uridine is the main substrate for #pyrimidine salvage, and uridine supplementation is given to patients with mutations in de novo pyrimidine synthesis #Vistogard #Xuriden 💊

🎯 We screened in +/- uridine and found the three pyrimidine enzymes as hits 1-2-3!

#CAD #DHODH #UMPS

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An atypical rearrangement in the binding pose of a potent inhibitor of human dihydroorotate dehydrogenase led to a reappraisal of inhibition of this enzyme #PyrimidineBiosynthesis #DHODH #StructureBasedDrugDiscovery t.co/qL5h0naQYh