The flexible loop in Methanococcus jannaschii dihydroorotase with substrate bound adopts both the loop-out and loop-in conformations #Dihydroorotase #MethanococcusJannaschii #PyrimidineBiosynthesis doi.org/10.1107/S205...

Genetic analysis of pyrimidine biosynthetic enzymes in Plasmodium falciparum
Absalon, S. et al.
Paper
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#PlasmodiumFalciparum #PyrimidineBiosynthesis #GeneticAnalysis

An atypical rearrangement in the binding pose of a potent inhibitor of human dihydroorotate dehydrogenase led to a reappraisal of inhibition of this enzyme #PyrimidineBiosynthesis #DHODH #StructureBasedDrugDiscovery t.co/qL5h0naQYh