The February issue is out now! Highlights include articles on the growing use of #AI in clinical #research, use of #DOACs in pediatric #thrombosis, public sector approaches to address unequal #CARTcell access, and more. Check out the full lineup here: https://ow.ly/LS7I50Y8gyW
#HemeSky #MedSky

📣 Efficacy and Safety of #DOACs for Superficial Vein #Thrombosis: A Systematic Review and Meta-Analysis ⬇️

📌 Boccatonda et al. found that DOACs have comparable efficacy to fondaparinux and an excellent safety profile in SVT

Read on TH: www.thieme-connect.de/products/ejo...

#Thrombosis #VascularSky

New #BJA #editorial discussing the ASRA vs PAUSE-2 approaches to #DOACs with #neuraxialanaesthesia and deep peripheral nerve blocks (#PNBs) – can a shorter interruption period offer comparable safety?

www.bjanaesthesia.org/article/S0007-0912(25)00...

Pharmacists’ Knowledge of Abnormal Uterine Bleeding in Women on Anticoagulant Therapy: A French Survey - Sibylle Frerebeau, Benjamin Planquette, Gabrielle Sarlon, Nicolas Gendron, 2025 Objectives This study aimed to assess the role of community pharmacists in managing abnormal uterine bleeding (AUB) in women on anticoagulant therapy, particula...

New study published:
💊 Only 7.8% of pharmacists in France 🇫🇷 were approached by women on anticoagulants with abnormal uterine bleeding
❌ 86.1% not have enough skills to adequately advise
📉 Uudercommunication must be addressed
journals.sagepub.com/doi/10.1177/...

#AUB #pharmacy #anticoagulants #DOACs

In this @thrombosis-update.bsky.social article, the authors found that underdosing #DOACs for nonvalvular atrial fibrillation is linked to higher risks of stroke and major bleeding compared to on-label dosing.
Read more here: www.sciencedirect.com/science/arti...
@lucynortcd.bsky.social #TruJournal

Direct oral anticoagulants or warfarin in patients with left ventricular thrombus after ST-elevation myocardial infarction: a pilot trial and a prespecified meta-analysis of randomised trials Randomized trial and pooled analysis comparing direct oral anticoagulants and warfarin for left ventricular thrombus in ST-elevation myocardial infarction.

Trial & meta-analysis show #DOACs (e.g., #Rivaroxaban) are as safe and effective as #Warfarin for left ventricular thrombus #LVT after #STEMI, with less major #bleeding risk.
#Anticoagulation @hmkyale.bsky.social @bbikdeli.bsky.social eli.bsky.social‬eurointervention.pcronline.com/article/dire...ls

📢 JUNE 2️⃣0️⃣2️⃣5️⃣ ISSUE ONLINE 🚩

🩸 #bleeding in #Women of #Childbearing Age on Anticoagulants for #VTE

🚨 Screening-Detected #afib and Blood Pressure Levels

🔬Plasma Proteome and #VTE risk

💊Plasma #DOACs levels in #afib: A Metanalysis

📖More at: tinyurl.com/5hk7kpfb

Direct oral anticoagulants: Challenging prescribing scenarios in everyday practice Direct oral anticoagulants (DOACs) are preferred to vitamin K antagonists for treating venous thromboembolism and nonvalvular atrial fibrillation, primarily because of comparable efficacy, consistent ...

www.ccjm.org/content/92/6...

#medsky #DOACs

Abelacimab Demonstrates Safety, Superior Bleeding Reduction Compared With Rivaroxaban in Atrial Fibrillation | ASH Clinical News | American Society of Hematology

The factor XI inhibitor #abelacimab may be a safer alternative to #DOACs for patients with atrial fibrillation #AFib, as the treatment led to a significant reduction in major and clinically relevant non-major #bleeding events compared with #rivaroxaban: ow.ly/xcpz50VM9eY
#HemeSky #Heme/Onc

Eines ist mit #Covid19 sicher: Es bleibt spannend!

#LongCovid #Antikoagulanzien #DOACs #VitaminKAntagonisten

⬇️❗❗❗

#NephroticSyndrome #Thromboprophylaxis With Direct Oral Anticoagulants #DOACs or Vitamin K Antagonists #VKAs

#VisualAbstract by @elbaonelida.bsky.social

www.kireports.org/ar...

🎯Updated @medscape.com Primary Care #Hack

🔥 #DOAC dosing for stroke prevention in #NVAF & kidney impairment🔥

🚨 #DOACs are not "fire & forget" drugs
💡 Do not use #eGFR; #CrCl should be used for drug dosing

PDF download link in comments below 👇🏾

@goggledocs.bsky.social @pharmrj.pharmsky.app

Standard-dose DOACs not necessarily better than reduced dose, study results suggest Patients with venous thromboembolism (VTE) who require extended treatment with direct oral anticoagulants (DOACs) do not necessarily gain an advantage from standard doses compared with reduced doses,…

Researchers have reported in #TheLancet that patients with #VTE who require treatment with #DOACs do not necessarily gain an advantage from standard doses compared with reduced doses

Anticoagulation in Atrial Fibrillation With Valvular Heart Disease | Journal of the American Heart Association

Read wonderful well-written #editorial published with our article @JAHA_AHA by @CatarinaACF @ClaudiaJorge19 #AHA reflecting on our work on ##anticoagulants #DOACs in #AF & #VHD @CukerMd @JamesLewisGIEpi @VUmedicine @PennMedicine

www.ahajournals.org/doi/10.1161/...

17b) A particularly appealing potential of a #FXI/XIa-targeted #anticoagulant is the ⬇️ bleeding risk they seem to offer vs #DOACs. Might this translate to patients on concomitant #OAPs?

4a) Use of #DOACs is indeed complicated to some extent by enzyme-related drug-drug interactions #DDI with, e.g., #SSRIs & #SNRIs, but especially by a pt's need for con meds that ALSO ⬆️bleeding, such as #ASA, #OAPs, & #NSAIDs. An anticoagulant that reduces bleeding might be easier to use.

3c) Which of these con meds can be used only w/caution with #DOACs for #stroke prevention in #AF?
a. #NSAIDs
b. colchicine
c. P2Y12 inhibitors
d. a & c
Answer in the comments!

Check out the results of our #multicenter study investigating #DOACs vs #Warfarin in patients with #LV_thrombus 🫀👇🏽

We found #similar rates of:

✅Thrombus resolution
✅All cause mortality
✅Bleeding events
✅Stroke/SE events

linkinghub.elsevier.com/retrieve/pii...

#CardioSky #ACCFIT

The rise and SURPRISE of the DOACs. St.Emlyn's The rise and use of DOAC oral anticoagulant medication in...

Great content from @stemlyns this weekend: 1/2 - @RCEMprof on #DOACs stemlynsblog.org/the-rise-and-surprise-of... #FOAMed