The chemical structure of RAY1216; P1′ denotes the warhead moiety and P1–P4 denote the other chemical moieties. b, The chemical structure of SARS-CoV-2 Mpro inhibitor PF-07321332 (nirmatrelvir). c,d, Chemical structures of telaprevir (c) and boceprevir (d), both of which inhibit HCV NS3/4A protease.

#MedSky🧪 #IDSky #Drugsrepurposing #Immunopharmacology Preclinical evaluation of #SARSCoV2 #Mproinhibitor RAY1216 shows improved #pharmacokinetics vs #nirmatrelvir .RAY1216 shows #antiviral activities against #SARSCoV2 variants vs those of #nirmatrelvir.

MedSky🧪#Immunopharmacology #Drugsrepurposing : Effectiveness of #azvudine on mortality in different types of #COVID19 patients. 🔑 concern for #Paxlovid administration was its effect on #cytochrome system & the resulting drug interactions .