It’s been great working with @raimonsunyer.bsky.social and his group @ub.edu in Barcelona on this #durotaxis project. Postdoc @alonso-matilla.bsky.social, co-advised by colleague Paolo Provenzano and myself, did the modeling work. Our preprint is posted now on biorxiv (link below).

Stay tuned: I’ll unpack the preprint in a thread 🧵 next week

#Durotaxis #Mechanobiology #CellMigration #Preprint

Since #durotaxis was described >25 years ago, most studies report cells migrating from soft → stiff

New work from my team at @ub.edu (in collaboration with D. Odde's lab) suggests we may have been missing the point all along...

🔥 Check out our new preprint here 👇
www.biorxiv.org/content/10.6...

Descubierto el 'GPS Mecánico' del Cáncer y la Fibrosis: La Durotaxis es una Nueva Diana Terapéutica Clave para el Envejecimiento Saludable. - Longenia Investigadores liderados por David Lagares han identificado cómo la rigidez del tejido activa la propagación celular metastásica y la fibrosis. El avance, publicado en Nature Cell Biology, propone el ...

🚨 BREAKING CIENTÍFICO: Durotaxis, el "GPS mecánico" del cáncer metastásico y la fibrosis. Bloqueando la interacción FAK-Paxilina (con JP-153), se detuvo la metástasis en modelos preclínicos. Longenia trabaja para que esta terapia sea accesible. Más:
acortar.link/0UY1fb
#Durotaxis #MecanoTerapia

3/8 #Durotaxis, cell migration along stiffness gradients, was described ~20 years ago. Until now, its role in disease remained speculative. We show durotaxis drives both metastasis and fibrosis.

1/8🚨 Thrilled to share our new paper in
@natcellbio.nature.com!
We show how tissue stiffness fuels cancer metastasis🎗️& lung fibrosis🫁 via #durotaxis, and how blocking mechano-sensing with #mechanotherapeutics 🎯💊could open a path to new treatments. 🔗 www.nature.com/articles/s41...