Kisspeptin peptide have reproductive & non reproductive roles in echinoderms. Kisspentins made from different precursors have opposing effects. Thabitha Islam @mauriceelphick.bsky.social lab, Queen Mary Univ London #EMBOneuropeptides
AND Its a wrap.......
Echinoderms are deuterostomes imp to understand neuropeptide evolution. Several nps are paralogous. Stomatostatin & allostanin systems are retained in Echinoderms, but either one lost in other phyla. Autotomy self limb amputation depends on nps! @mauriceelphick.bsky.social QMUL #EMBOneuropeptides
Transient, local galanin expression in mouse brain & is imp for neuronal connectivity during whisker formation through retrograde signalling. Zsofia Hevesi, Harkany lab, Med Univ Vienna, #EMBOneuropeptides
Over-expressing Toll R neuronally does not change feeding but alters the metabolic status of Drosophila through a neuropeptide. Bhavna Pydah, Das lab, NCCS #EMBOneuropeptides
Drosophila show emesis on toxin ingestion & exhibit learned anticipatory emesis. Like in mammals, serotonergic & dopaminergic neurons needed for emesis. Gaurav Das, NCCS #EMBOneuropeptides
Stress evolved to adapt to challenges, but can also be maladaptive. Zebrafish Galanin producing neurons respond to stress & regulate stress-related behviour. Alessandro Filosa, MDC Berlin #EMBOneuropeptides
Structural and behavioural studies with cone snail toxin, Conopressin-K and its analogues. Rajesh Sonti, NIPER Hyd #EMBOneuropeptides
Activation of ACC neurons rescues spared nerve injury model induced mechanical allodynia & have anxiolytic effects. Yatika Chaudhary, Barik lab, IISc #EMBOneuropeptides
Acute stress suppresses acute & chronic itch in mice. LH stress neurons modulate acute & chronic itch in a bidirectional manner. Works out the circuit to known for stress modulated itch response. Jagat Narayan Prajapati, Barik lab, IISc #EMBOneuropeptides
Transition bet local to global search driven in part by food. Role of a neuropeptide, FLP-15, & its receptor in both searches. Umer Saleem Bhat @kavita-babu.bsky.social IISc #EMBOneuropeptides
Memory overshawdoing seen in flies in an aversive memory conditioning assay where shock is paired w/ 2 odors. No overshadowing in appetitive conditioning. Aditi Mishra, Waddell lab, Univ Oxford #EMBOneuropeptides
Stop codons at sites of natural caspase cleavage in ADNP, are implicated in Autism & AD. A role in DNA damage is proposed. Shula Shazman w/ Gozes lab, TelAviv Univ #EMBOneuropeptides
Activity profiles of Drosophila are individual. Genetics, environment, stochasticity affects individual variability where stochasticity is the most imp. Morphology of PDF neurons & PDF puncta number co-relate w/ individual acty. Muhammad Haidar, Linneweber lab @FU_Berlin #EMBOneuropeptides
Earth's rotation provides periodicity and there are many circadian clocks in an organism. Eclosion pattern reflects developmental & circadian timing requires both a central & peripheral clock. Central master clock➡️ sNPF➡️ PTTH➡️ Peripheral clock. Christian Wegener Univ Würzburg #EMBOneuropeptides
Many fly behaviours are under circadian control. Rhythmic locomotion is modulated by temperature. PDF is necessary to suppress activity in warm temps in the middle of the night. Temp cues could be strong drivers of changes in circadian clock organization. Sheeba Vasu, JNCASR #EMBOneuropeptides
@viditavaidya.bsky.social TIFR
says talk to people instead of worrying about sharing data. Function with a degree of trust. You will also get other ideas.
Panel discussion #EMBOneuropeptides
Openness in communication is very imp for resolving problems in a conflict. Christian Wegener, Univ Würzburg
Pitch your idea well to your PI to convince them to allow you to take on a side project @laurabduvall.bsky.social Columbia
Panel discussion #EMBOneuropeptides
Have a back up project during your PhD in case projects fail @viditavaidya.bsky.social TIFR
@kavita-babu.bsky.social IISc describes her path of developing her own projects often independent of her PhD supervisor.
Panel discussion #EMBOneuropeptides
When people say something to make you angry. Listen, use it and move on. Rejections: jobs, papers: are part of the journey. Know when to drop a project, discuss with PI & others.
Panel discussion Mario de Bono, IST Austria
#EMBOneuropeptides @embopress.org
Aβ42 oligomers seen in early stages of Alzheimer's cause neuronal hyperexcitability. Hyperexcitability turns on signalling to ⬆️ 2 pore K+ channels in AD models & w/ Aβ42 exposure to turn down excitability. A potential neuroprotective mechanism in early AD. Swagata Ghatak, NISER #EMBOneuropeptides
Nose poke positive reinforcement conditioning behaviours depends on CART & GABA. Conditioning uses CART & GABA to alter chromatin at the Orexin promotor & increase its expression. Amul Sakharkar, SPPU #EMBOneuropeptides
C. elegans have long-term associative memory requires secretion from trained worms which can be transferred to naive worms. This effect is cue specific and may occur through EVs. @kavita-babu.bsky.social IISc #EMBOneuropeptides
Activity based anorexia model leads to ⬆️ NPY expression during food restriction. NPY acts partly thru Y1R signalling in maintaining energy balance during activity w/ food restriction Lei Zhang, Herzog lab, Univ New S. Wales #EMBOneuropeptides
Insulin-like peptides are key regulators of aging through transcription factors eg DAF-16/FOXO. Single cell resolution TURBO ID of DAF-16 identifies a kinase that inhibits DAF-16. Mario de Bono, IST Austria. #EMBOneuropeptides @embopress.org
GPCR promiscuity in neuromodulation. NLP-12 secretion from the mechanosensory DVA is required for food search turning through CKR-1. Distinct CKR-1 circuits are recruited during on- or off- food transitions. Raja Bhattacharya, Amity Univ Kolkata #EMBOneuropeptides
Associative learning on toxin ingestion & malaise. Toxin-induced emesis and shows learned anticipatory emesis via malaise on re-exposure to the same cue. Emesis depends on Trp channels. Rashmi Karunakaran, Gaurav Das lab, NCCS #EMBOneuropeptides
CART regulates the substantia niagra dopaminergic activity via TRPV2 channels. Modulation of TRPV2 alters locomotor acty & provides a drug target for PD. Sumela Basu, Singru lab NISER #EMBOneuropeptides
Sleep is required for memory consolidation in fed flies. Sleep-dependent & independent memories are via different circuits. Ethanol fed flies sleep better but drives a switch to sleep-independent memory consolidation. Switch via a neuropeptide. Nitin Chouhan @TIFRScience #EMBOneuropeptides
Catestatin occludes the pore of the nicotinic AchR. Catestatin administration reduces anxiety like behaviours, mitigates stress effects in a rat PTSD model. Manoj Dandekar,
NIPER Hyderabad #EMBOneuropeptides
ADNP has a major role in microglia homeostasis: regulates the TBK1 neuroinflammation pathway, regulates autophagic flux, mitochondrial respiration & glycolysis activity. David Pozo Perez, Univ Seville #EMBOneuropeptides
