🤷♀️Can replacing vit K in #CKD reduce vascular calcification?
🤷♀️Better activation of calcification inhibitors with vit K
🤷♀️BUT not enough to see difference in calcification
🤷♀️Caveat there are ongoing studies
@jennifer_s_lees
@ERAkidney prize winner 2022
#ERA22...
#ERA22 session in microbiota in CKD, from discussions:
🐻 The bear has seasonal differences in gut microbiota. During hibernation, microbiota had reduced diversity:
⬇️ Firmicutes and Actinobacteria
⬆️Bacteroidetes
@TeamBear22 #AnimalHouse #NephMadness
🔗...
Nice talks #sglt2i #finerenone
🌸#sglt2i mechanism of action unclear
🌸Both offer Cardio renal benefits
🌸Potassium ⬆️ with MRAs but less than thought
🌸Sick day rules important but restarting just as important
🌸Roll on #EMPA-KIDNEY
#ERA22 #DMera22 #CVera22 #FCera22
🧠 Cognitive impairment in CKD by @GianniCapasso4: a major issue in CKD and a starting point for many research hypotheses. Great @ConnectCost neuro-nephrology session at #ERA22 🤩 @ERAkidney
🧠 Great talk by Gaye Hafez : Albuminuria is a sensitive marker for cognitive disorders and endothelial damage @ConnectCost #ERA22 @ERAkidney
So maybe the answer to our P-lowering ideal drug would be a pan-P transporter inhibitor: promising in murine models, but just passed by phase 1b trials #ERA22
📌Can you think of another drug class that inhibits NHE3 at intestinal levels?
@ChristosArgyrop
could tell us more about #flozination
⁉️ Question: do we know more about glifozins and P? Could they lower the P? #ERA22
💊 Tenapanor decreases burden pill, for pts with CKD, but remains unapproved by FDA- mostly because of lack of real efficacy evidence (same P- CV outcomes discussion) #ERA22
🧵💊 Tenapanor is an NHE3 blocker, initially used as a treatment for irritable bowel syndrome with constipation predominance. Now it is a promising drug when comes to P lowering. #ERA22
Let's take a look at a mix of Nicotinamide and Lanthanum. Same discussion: lower P and FGF23, but same dead-end when talking about hard end-points (see the Landmark trial) #ERA22
⁉️ But, it's not that simple, having so many mechanism to act on.
❓Should we use old Nicotinamide? What about adverse effects? #ERA22
🧵❤️🩹 Maybe the 2 awaited pragmatic trials will bring more info about CV outcomes & P lowering #ERA22
🧵⁉️In theory, we know that lowering P would decrease CV outcomes. Yet, no studies to show this. So it's a matter of causality or there is only association? #ERA22
🧵Phosphorus correlates with species longevity: the higher P levels, the lower life expectancy.
📌 Phosphorus: the good, the bad & ugly stuff in CV disease. #ERA22
Amazing presentation about possible new ideas for hyperphosphatemia treatment in MBD-CKD #ERA22
My colleague @ApetriiMugurel, just nailed it! And couldn't be done without @accovic support
Brain changes in nephroCOVID19 🧠🦠 : a central role of TNF-alpha ? An exciting talk by Davide Viggiano #ERA22 @ConnectCost @ERAkidney
@jennifer_s_lees
🥁Cystatin C for the win 🥁
Based on @uk_biobank data.
Some inherent limitations but eGFR using cystatin C risk stratifies CKD even when eGFRcr is >60
#ERA22 #FCera22
Post hoc analysis of SUSTAIN 6 trial @KatherineTuttl8 from🇺🇸 with #semaglutide v placebo far less likely to move to a higher KDIGO risk category - changes in GFR & albuminuria contribute to this. Assessment re semaglutide renal protective effects in progress 😊 #ERA22 #MINIera22
The first moderated mini oral session chaired by @mcq_emily @EdoardoMelilli is running smoothly & is well attended. Nice initiative @ERAkidney #ERA22 🌟
Prof Luyckx #inequality in kidney health care. Difficult choices as limitation of resource & lack of awareness for #ckd Ppl die cos inability to offer dialysis. Covid has magnified these inequalities. We must act. Put K for kidney back in the global alphabet. #PLENera22 #ERA22
Superstar! Congratulations @jennifer_s_lees La mia amica & @ERAkidney prize winner 🌟🌟🌟🌟🌟🙌🥳😍#ERA22 #PLENera22
Great work @CKJ_EiC and looking forward to having @PepaSolerR take the helm as the first woman editor #allthewoman #ERA22 sortie in the background is appropriate if slightly unfortunate 😂
Biopsy course for the 1st time from @ERAkidney organised by @mcq_emily & Kai Lopau 🏴 🇩🇪 Everyone v enthusiastic 😍 Some more than others @jennifer_s_lees 🙌 & some friendly rivalry between hands on courses as @LoretoGesualdo ‘steals’ an ultrasound machine from next door 🙈#ERA22
Glad to hear you @Tiff_Caza! In the clinic, with my students, all listening to great presentation! #ERA22
And 💣… game-changer Ab for MCD discovery #ERA22
Reminder of @GlomCon great presentation, and also for the great enthusiasm of discovery listen to @NephJC_Podcast episode
If was known until ’70s. So why anti-nephrin Ab were not discovered earlier? Dusting is the 🗝word here #ERA22
