That’s a wrap on the ER Redox meeting in Namur! Four days of fantastic science from speakers and poster presenters. Huge thanks to Alison Forrester and Emma Fenech for a seamless event. The University of Namur was a fantastic and welcoming host! #ERRedox2025
Already looking forward to #ERRedox2027
Jueyin He / Lei Wang (Institute of Biophysics, Beijing) with exciting data with catch receptor-mediated Golgi retention of Fam20A-Fam20C kinase complex and how it tunes secretome phosphorylation during lactation. #ERRedox2025
Lei Wang (Institute of Biophysics, Beijing) gave a fantastic retrospective on past ER redox sessions—complete with pictorial proof that some of our senior colleagues once had black hair! #ERRedox2025
Marco Dalla Torre (Vita-Salute San Raffaele University, Milan): intriguing images of secretory pathway reorganization during endometrial stromal cell decidualization. Lead to a fun discussion after the seminar. #ERRedox2025
Susanne Steigleder (University of Cologne) showed exciting data on the role of the intramembrane protease RHBDL4 in regulating protein trafficking. #ERRedox2025
Francescopaolo Iavarone (TIGEM, Pozzuoli) interesting data from mouse models show that Fam134c and Fam134b control axonal endoplasmic reticulum architecture in vivo #ERRedox2025
Chian Yang (Oxford, UK) tells us about her development of an elegant ratiometric fluorescence-based reporters to screen for small molecule inhibitors of Hrd1-mediated ERAD. #ERRedox2025
Céline Schaeffer (Vita-Salute San Raffaele University, Milan) tells us about the Integrated Stress Response arising from different pathogenicity of various renin mutations. Interesting differences between mutants. #ERRedox2025
Day 4 of the ER Redox meeting in Namur! Three intense days of fun science and great conversations about research and life. Both my brain and liver are getting a serious workout from the sessions and networking! #ERRedox2025
Important issues in science and academia: Sustainability in the lab. A discussion led by Alison Forrester @aforrester.bsky.social, who has also started green initiatives at the university of Namur. Sustainable science starts at the bench - small shifts, big impact. #ERRedox2025
Céline Philippe (University of Rennes). The Unfolded Protein Response brings about a considerable change in the alternative splicing program. Interesting groups of genes that are affected! #ERRedox2025
Adriana Ordoñez (soon to start her group at UCAM, Murcia!) gives us fascinating insights into where her group will go, in looking at adaptive genes that modulate antitrypsin polymerisation toxicity - linking to the Unfolded Protein Response. #ERRedox2025
Joanne Tung (University of Cambridge) showed beautiful structural data with crystal structures, cryoEM to suggest a basis for Agr2-mediated repression of stress signalling from the ER. #ERRedox2025
Motonori Matsusaki (Tohoku University, Sendai) presented nice biochemical data suggesting that higher-order oligomerization of IRE1 luminal domain modulates the Unfolded Protein Response #ERRedox2025
Masaki Okumura (Tohoku University, Sendai): Intriguing data suggesting Ca2+-driven P5 condensate formation ensures proinsulin folding fidelity #ERRedox2025
Work described in their preprint
www.biorxiv.org/content/10.1...
The networking may have gone on long and raucously on day 2 of the ER Redox meeting, Namur (Belgian beer😳), but we’re all here bright-eyed and enthusiastic for Day 3. Thanks to Alison @aforrester.bsky.social and Emma Fenech for assembling this stellar lineup and for a fun time in Namur. #ERRedox2025
Really fun talk to wrap up a great day at the ER redox meeting! Sophie Janssens (VIB-UGent Center for Inflammation Research) with two stories. Regulation of IRE1b function by the mucin chaperone AGR2 in goblet cells. Also intriguing data on PDIA5 in dendritic cells. #ERRedox2025
Francisco Laurindo (University of Sao Paulo) The ER-Extracellular connection. Intercellular redox communication - PDIs play an important role. Interesting secretory route for PDI! Location and interactors are key. #ERRedox2025
Shohei Fujii, (Kyushu University, Fukuoka): A newly developed calcium imaging system reveals the true calcium atlas in the early secretory pathway! Incredible changes in Calcium from the ER to the Golgi. I’ve been waiting for tools like this one! #ERRedox2025
Marcel van Lith (University of Glasgow) told us about real time monitoring of cytosol/ER NADP(H) redox balance. Technical glitches during the presentation meant that we had a fun discussion halfway through the seminar! #ERRedox2025
Shingo Kanemura (Tohoku University, Sendai) describes useful therapeutic strategy arising from his studies on reductive unfolding by extracellular PDI, inactivating viral spike proteins #ERRedox2025
First up for the day. Chika Tsutsumi, (Kyoto Sangyo University) describes a novel Zn2+-dependent antioxidation by ERp18 in the ER #ERRedox2025
Welcome to day 2 of the ER & Redox Club Meeting at Namur, Belgium! Another exciting set of talks for the day. #ERRedox2025
Wonderful start to the #ERRedox2025 Club meeting in beautiful Namur, Belgium with old and new friends!
For the inaugural Neil Bulleid Memorial Lecture: Arvin Pierre tells us how activation of the UPR sensor ATF6α is regulated by its redox-dependent dimerization #ERRedox2025
Memorial to Neil Bulleid led by Ineke Braakman and Roberto Sitia. Neil pioneered work on PDIs, innovated new models - laid foundations for discoveries in collagens, chaperones and oxidative folding in the ER.
Neil was kind, supportive, enthusiastic and co-founded the ER redox meeting!
#ERRedox2025
Joe Chambers @joechambers.bsky.social (University of Cambridge, UK). Z-mutant a1AT forms pathogenic polymers, accumulate in hepatocyte ER. Somatic escape variants of of the gene itself come up in a1-antitrypsin deficiency. #ERRedox2025
Haddas Saad (Tel Aviv University, Israel) Class I alpha-1,2 Mannosidases IB and IC: Subcellular localization surprisingly different between the two. Interesting roles in mammalian secretory protein quality control #ERRedox2025
Kevin Michael Meighen-Berger, (TU Munich): QC for ER membrane proteins not so well known. Elegant biochemistry and modelling shows that the EMC acts as a chaperone for labile transmembrane domains. #ERRedox2025
Belinda Hall, (University of Surrey, UK) tells us about Buruli ulcers and how its treatment drug mycolactone works. It's a Sec61 inhibitor, which ends up targeting Vacuolar ATPase assembly and disrupts lysosomal function, compromising cellular stress recovery responses #ERRedox2025
