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Thanks to all participants & experts! It was such a great discussion! 🙌🏼

See you in May 👋🏼🔜 #ESHREjc

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See you next time! #ESHREjc

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Also a big thank you to our fantastic moderators for leading such an engaging and insightful discussion 👇

@gliperis.bsky.social
@dkalaitzopoulos.bsky.social
@juanjo-fraire.bsky.social
@ribeirosara.bsky.social

Your energy and thoughtful moderation made this #ESHREjc truly outstanding 👏

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A big thank you to our amazing experts for making this discussion truly outstanding 👇

@prof-lotti.bsky.social
@smdsresearch.bsky.social
@drdanielmarcu.bsky.social
@mvazquezlevin.bsky.social
@drlucaboeri.bsky.social

Your expertise and insights made the difference. #ESHREjc

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A big thank you to everyone who joined this lively edition of the #ESHREjc! 🦋

It was a pleasure to see such engaging discussions and insightful contributions from all participants and experts.

Truly grateful to have shared this with such a fantastic community... looking forward to the next one! 🙌

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Many thanks to all participants, experts and to @mr-att.bsky.social and his team for leading this lively edition of the #ESHREjc 🦋
See you next time! 🙌

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But I agree we should have discussed more the propensity score matching approach 😅 #ESHREjc

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I found this in the materials and methods #ESHREjc

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These are indeed large numbers 😅 #ESHREjc

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No increase in miscarriage for various subgroups in the study. Does the data here challenge the hypothesis of higher risk of miscarriage with poor sperm quality 🤔? #ESHREjc

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Another issue is how to communicate lower treatment success rates. Many still prefer to pursue biological parenthood despite lower odds of success #ESHREjc

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I’m struggling with table 2 - specifically fert rate (FR). I assume control (N) couples and those undertaking treatment with donor sperm were treated with IVF, whereas OAT-S and azoospermia-H (and MMF) were ICSI? Yet there isn’t a significant difference between these with PSM 🤔? #ESHREjc

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Is anyone else blown away by the numbers treated at a single reproductive centre in this study? Nearly 15000 cycles in less than 5yrs!! 💪💪 #eshreJC
Differences seen in outcomes are unlikely to be attributable to different lab practices…

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💬 Q4 Summary is out!

Good counselling isn’t just prognosis.

👉 Clear steps, follow-up, and support are key to reduce patient distress.

#ESHREjc

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We call it “fertility care” but for men it’s mostly reactions to problems that are addressed after they appear.

Awareness and education should start early, right after puberty.

Isn’t it time male fertility became part of a structured, age-based plan before it’s too late?

#ESHREjc

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🔬 Q3 Summary is out!

Why do controlled models show weaker male effects?

👉 Oocyte repair capacity may mask sperm damage... but only up to a point.

#ESHREjc

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🧬 Q2 Summary is out!

OAT-S and NOA are not one entity.

👉 Biology, epigenetics, and confounders all interplay... how much is intrinsic vs contextual?

#ESHREjc

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🧠 Q1 Summary is out!

Severe male factor may not affect neonatal outcomes... but it impacts time, cycles, and patient burden.

👉 Time-to-live-birth matters.
#ESHREjc

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Multicentre pragmatic randomised controlled feasibility trial of fertiShare, a brief eLearning course to increase fertility staff performance when sharing bad news with their patients – a protocol Introduction Sharing bad news (SBN) is a recurring and stressful challenge for fertility staff and patients. Suboptimal SBN is associated with staff burnout, patient dissatisfaction with care and lack...

Looking forward for FertiShare results 👉 doi.org/10.1136/bmjo...
#ESHREjc

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Agree! Research in the fertility-specific context is still needed. Despite growing attention, we lack emprical evidence on how doctor-patient communication improves patients’ decision-making process and emotional adjustment in this field #ESHREjc

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However, many of us don’t receive formal training. A practical solution could be to introduce university courses or workshops focused not only on research communication, but also on clinical interactions—incorporating simple frameworks like the SPIKES protocol into everyday practice. #ESHREjc

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There is solid evidence from fields like oncology that structured communication models, such as the SPIKES protocol, and shared decision-making frameworks, improve patient understanding, help reduce decisional conflict and set realistic expectations. #ESHREjc

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😏 At the same time, many of you raised important doubts about how much of this effect is truly biological versus context-dependent.
💬 A rich, nuanced discussion, thank you all for your contributions! 🙏🏻
Now we look forward to the summary slides, coming in a few hours 👀
#ESHREjc

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🤔 There’s growing agreement that male infertility is not one entity, and that severe phenotypes may impact outcomes more than we previously acknowledged, especially in terms of time and efficiency to live birth.🫨
#ESHREjc

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1/3 🚀🚀🚀 As this #ESHREjc discussion comes to a close, a few key themes are emerging 👇
We’ve questioned long-standing assumptions, particularly whether ICSI truly overcomes male factor infertility, and highlighted the gap between improving semen parameters and achieving live birth.

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#ESHREjc

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#ESHREjc

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#ESHREjc

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Training can start as early as during graduation and continue throughout professional life to address the specificities of fertility care. While evidence in this field is limited, general studies show that communication training improves patient satisfaction and physicians' self-efficacy #ESHREjc

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Every couple is different and should be approached individually, with clear expectation management.
The focus should be on strategies to improve outcomes, including antioxidant supplementation, which, although still under investigation, may improve semen parameters, particularly in OAT-S #ESHREjc

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