EXOSC10 haploinsufficiency causes primary microcephaly by derepression of Sonic hedgehog signalling Ulmke et al. show that mutations in EXOSC10 cause microcephaly. In mice, loss of Exosc10 leads to premature differentiation of neural progenitor cells, dis

#EXOSC10 #RNAExosome #RNA

academic.oup.com/brain/advanc...

Interesting! #RNAExosome #RNA
#EXOSC10 -mediated pre- #tRNA #surveillance safeguards #neuron survival
Yoshinori Nishimoto, Xin Yang, Richard I. Gregory

www.biorxiv.org/content/10.1...