Mechanistic insights on #Efaecalis effects in #Cdiff motility by @ashleyweiss.bsky.social #clostpath14

#HostPathogen models for the study of #UTI #Infections🔬. Incredible work from Abell-King et al. exploring #multispecies #bacterial behaviour using clinical strains and human bladder models 🧫. Read it here: buff.ly/4aGNxKD #PathogDis #KPneumoniae #Efaecalis #UPEC

4/🧵 We also discovered how #Efaecalis impacts macrophages, the immune cells responsible for resolving inflammation. Our findings offer new insights into the immunosuppressive role of #Efaecalis in wound infections, shedding light on a critical area of research. 💡

3/🧵 Our study revealed unique genetic and metabolic changes in infected wounds, showing how #Efaecalis can create an environment that actually slows down healing. 🦠🧬 #Efaecalis triggered a premature and incomplete transition in keratinocytes cells. 🤯

A single-cell atlas of E. faecalis wound infection reveals novel bacterial-host immunomodulatory mec... bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

1/🧵 Exciting news! 📢@ThibaultLab @KimInGeneva latest research on wound infections and healing is out now. We delved deep into the role of E. faecalis in chronic wounds, uncovering some fascinating findings. 🩹🦠
#WoundInfections #scRNA-seq #Efaecalis
 
doi.org/10.1101/2023...