Electrophilic fragment screening using native mass spectrometry to identify covalent probes for surface cysteines Covalent chemical probes form a covalent bond with a target protein of interest to elicit an effect and methods to identify and characterise them are needed. We developed a native mass spectrometry (n...

Klose et al (2025) #Electrophilic #fragment screening using native mass spectrometry to identify covalent probes for surface cysteines. Aust J Chem 78 CH25081 #FBD #FBLD #FBDD #MS #ChemBiol #MedChem #cheminformatics #OpenAccess #chemsky 🧪
doi.org/10.1071/CH25...