#EnzymeTech

What is the main goal of our projects?

We discover and optimize enzymes to perform new-to-nature reactions under mild, green conditions 🌿—cutting steps, reducing waste, and pushing the frontiers of innovation 🚀. Curious? We’ll be sharing more soon!

#enzymetech #innovation

Biocatalytic enantioselective formation and ring-opening of oxetanes | Nature Communications Although biocatalysis offers complementary or alternative approaches to traditional synthetic methods, the limited range of available enzymatic reactions currently poses challenges in synthesizing a diverse array of desired compounds. Consequently, there is a significant demand for developing novel biocatalytic processes to enable reactions that were previously unattainable. Herein, we report the discovery and subsequent protein engineering of a unique halohydrin dehalogenase to develop a biocatalytic platform for enantioselective formation and ring-opening of oxetanes. This biocatalytic platform, exhibiting high efficiency, excellent enantioselectivity, and broad scopes, facilitates the preparative-scale synthesis of chiral oxetanes and a variety of chiral γ-substituted alcohols. Additionally, both the enantioselective oxetane formation and ring-opening processes are proven scalable for large-scale transformations at high substrate concentrations, and can be integrated efficiently in

Discover how protein engineering of a unique halohydrin dehalogenase enables enantioselective oxetane formations and ring-opening! Biocatalysis innovation at its best! #EnzymeTech PMID:39885154, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56463-z #Medsky 🧪