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Bleeding Risk with Apixaban vs. Rivaroxaban in Acute Venous Thromboembolism | New England Journal of Medicine Apixaban and rivaroxaban are the oral anticoagulants most frequently used to treat acute venous thromboembolism. However, uncertainty remains about the difference in bleeding risk between the two m...

COBRA trial link

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SOHO trial link

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www.nejm.org/doi/ful...

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TAPER-V trial link here

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jamanetwork.com/jour...

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Trial link here

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evidence.nejm.org/do...

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ED peer navigator trial

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jamanetwork.com/jour...

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The DIALIZE-Outcomes trial

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www.kidney-internati...

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Study link here

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#Orthopedics
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jamanetwork.com/jour...

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LATITUDE trial here

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www.nejm.org/doi/ful...

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Link here

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jamanetwork.com/jour...

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Trial link here

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www.thelancet.com/jo...

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Study link here

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jamanetwork.com/jour...

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Study link here

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jamanetwork.com/jour...

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Link here

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onlinelibrary.wiley....

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Study here

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www.acpjournals.org/...

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Study here

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jamanetwork.com/jour...

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Prebiopsy Steroids and Diagnostic Yield in Diffuse Large B-Cell Lymphoma This cohort study evaluates whether corticosteroid use before biopsy is associated with the diagnostic yield in patients with newly diagnosed diffuse large B-cell lymphoma.

Study link here

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Trial here

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#Neurosurgery

www.nejm.org/doi/ful...

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Trial here

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jamanetwork.com/jour...

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Trial here

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www.sciencedirect.co...

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DANFLU-2 trial

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www.nejm.org/doi/ful...

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AQUATIC Trial here

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www.nejm.org/doi/ful...

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Apixaban for Extended Treatment of Provoked Venous Thromboembolism | NEJM The appropriate duration of anticoagulation for venous thromboembolism (VTE) in patients who have a transient provoking factor (e.g., surgery, trauma, or immobility) and concomitant enduring risk f...

HI-PRO Trial here

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Digitoxin in Patients with Heart Failure and Reduced Ejection Fraction | NEJM The therapeutic efficacy of the cardiac glycoside digitoxin in patients with heart failure and reduced ejection fraction is not established. In this international, double-blind, placebo-controlled ...

DIGIT-HF trial link here

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#Cardiology

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Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction | NEJM The benefit of beta-blockers after myocardial infarction in patients with a preserved left ventricular ejection fraction (LVEF) is unclear. We conducted a meta-analysis at the individual-patient le...

Meta analysis here

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LIBERATE-D Trial here

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jamanetwork.com/jour...

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Increasing the Potassium Level in Patients at High Risk for Ventricular Arrhythmias | NEJM Hypokalemia and even low-normal plasma potassium levels increase the risk of ventricular arrhythmias among patients with cardiovascular disease. An assessment of a strategy of actively increasing p...

POTCAST trial here

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Reduction of Antihypertensive Treatment in Nursing Home Residents | NEJM Among older adults with frailty, evidence on the benefits and risks of discontinuing antihypertensive drugs is limited. In a multicenter, randomized, controlled trial conducted in France, we assign...

Trial here

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Safety Impact We're voluntarily sharing our safety data to demonstrate how the Waymo Driver is making roads safer in the places we currently operate. See the stats.

Waymo safety data here

More rigorous research needed, but it's the most promising solution to date

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#HealthPolicy

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In shot across Big Pharma's bow, California will sell its own insulin Delivery of the state-branded drug makes good on a longstanding promise by Gov. Gavin Newsom.

News story here

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#Endocrinology

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Tranexamic Acid in Patients Undergoing Noncardiac Surgery | NEJM Perioperative bleeding is common in patients undergoing noncardiac surgery. Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding. We conducted a trial involving patien...

Trial link

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