Loss of nsp14-exonuclease activity impairs the replication, proofreading, fitness and pathogenesis of SARS-CoV-2 Coronaviruses (CoVs) replicate their RNA genomes with increased fidelity than other RNA viruses, a mechanism mediated by the proofreading and recombination activities of the exoribonuclease domain of ...

Our new preprint on #SARSCoV2 nsp14 #exonuclease function in replication fidelity and fitness. ExoN- viruses are attenuated in vitro and in vivo but w/o #interferon signaling replication is largely restored! Suggests nsp14 plays a role in innate antagonism in vivo www.biorxiv.org/content/10.6...

Grant writing w ballet rehearsal on the side. #coronavirus #exonuclease is cool shit. Guides replication fidelity and we think masterminds control of the host response. Oh my. If only my 12 pages were done? #grantwriting #acadreamia #nih #coronavirus

Schematic of WRNexo function in Drosophila intestinal stem cells (ISCs). WRNexo upregulation and Hsc70-3/Bip translocation to nuclei occur with injury/aging. WRNexo interaction inhibits Hsc70-3/Bip, increasing ER stress, which promotes ISC proliferation via ROS-JNK signaling.

#WernerSyndrome mutations cause premature #aging, but what's the normal role of this #exonuclease? This study shows that the #Drosophila homolog WRNexo regulates the ER's #UnfoldedProteinResponse in intestinal #StemCells, promoting gut #regeneration after injury @plosbiology.org 🧪 plos.io/42XBYfH

Schematic of WRNexo function in Drosophila intestinal stem cells (ISCs). WRNexo upregulation and Hsc70-3/Bip translocation to nuclei occur with injury/aging. WRNexo interaction inhibits Hsc70-3/Bip, increasing ER stress, which promotes ISC proliferation via ROS-JNK signaling.

#WernerSyndrome mutations cause premature #aging, but what's the normal role of this #exonuclease? This study shows that the #Drosophila homolog WRNexo regulates the ER's #UnfoldedProteinResponse in intestinal #StemCells, promoting gut #regeneration after injury @plosbiology.org 🧪 plos.io/42XBYfH

Schematic of WRNexo function in Drosophila intestinal stem cells (ISCs). WRNexo upregulation and Hsc70-3/Bip translocation to nuclei occur with injury/aging. WRNexo interaction inhibits Hsc70-3/Bip, increasing ER stress, which promotes ISC proliferation via ROS-JNK signaling.

#WernerSyndrome mutations cause premature #aging, but what's the normal role of this #exonuclease? This study shows that the #Drosophila homolog WRNexo regulates the ER's #UnfoldedProteinResponse in intestinal #StemCells, promoting gut #regeneration after injury @plosbiology.org 🧪 plos.io/42XBYfH

Human REXO4 is Required for Cell Cycle Progression Human REXO4 is a poorly characterized exonuclease that is overexpressed in human cancers. To better understand the function of REXO4 and its relationship to cellular proliferation, we have undertaken ...

#REXO4 #Exonuclease #rRNA
#CellCycle

www.biorxiv.org/content/10.1...