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FDA approves extension of Eylea HD dosing intervals The FDA approved an extension of dosing intervals for Eylea HD in patients with diabetic macular edema and wet age-related macular degeneration, Regeneron Pharmaceuticals, Inc. announced. The approval, which extended the dosing intervals up to every 20 weeks, also includes an update to the Eylea HD (aflibercept 8 mg, Regeneron) label to include 2-year data from “the pivotal” PULSAR and PHOTON trials, according to a press release. “The potential for needing only two or three Eylea HD injections a year to manage certain retinal diseases is an exciting advance that could benefit

Ophthopedia Update: FDA approves extension of Eylea HD dosing intervals: The FDA approved an extension of dosing intervals for Eylea HD in patients with diabetic macular edema and wet age-related macular degeneration, Regeneron Pharmaceuticals, Inc. announced.
The… #ophthalmology #eye #eyenews

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K.C. Pharmaceuticals recalls more than 3 million eye drop bottles Editor’s note: This is a developing news story. Please check back soon for updates. K.C. Pharmaceuticals is recalling more than 3.1 million bottles of eye drops due to “lack of assurance of sterility,” according to the FDA. The eight affected products, totaling 3,111,072 individual units, have been distributed throughout the U.S. It is a class II recall, meaning the drops may cause temporary or reversible adverse effects, or have a low probability of causing severe adverse effects. The following products have been recalled:

Ophthopedia Update: K.C. Pharmaceuticals recalls more than 3 million eye drop bottles: Editor’s note: This is a developing news story. Please check back soon for updates.
K.C. Pharmaceuticals is recalling more than 3.1 million bottles of eye drops due to “lack of… #ophthalmology #eye #eyenews

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Zenkuda superior to sham in phase 3 diabetic retinopathy study Zenkuda demonstrated superiority over sham in patients with diabetic retinopathy in the phase 3 GLOW2 study, according to a press release from Kodiak Sciences. In the confirmatory study, patients with proliferative diabetic retinopathy and mild diabetic macular edema and patients with moderately severe to severe diabetic retinopathy were randomly assigned to receive Zenkuda (tarcocimab tedromer) intravitreal injection (130 patients) or sham injection (125 patients), with dosing at baseline and at weeks 4, 8, 20 and 44. By the end of the study, all patients were on a 6-month dosing interval. At

Ophthopedia Update: Zenkuda superior to sham in phase 3 diabetic retinopathy study: Zenkuda demonstrated superiority over sham in patients with diabetic retinopathy in the phase 3 GLOW2 study, according to a press release from Kodiak Sciences.
In the confirmatory… #ophthalmology #eye #eyenews

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Patients want high-quality care, provider choice, affordability Click here to read the Cover Story, “Paralympian initiates advocacy for eye care.” A key factor to generate new patients for an eye care practice is patient word-of-mouth referrals. To maximize patient advocacy, we must generate patients who are satisfied with their care experience. In addition, happy patients also make for happier practice employees and doctors. Arguably, along with providing high-quality care, generating happy patients satisfied with their care experience is core to our purpose as physicians. To the classical saying “happy spouse, happy house,” we can add “happy patients,

Ophthopedia Update: Patients want high-quality care, provider choice, affordability: Click here to read the Cover Story, “Paralympian initiates advocacy for eye care.”
A key factor to generate new patients for an eye care practice is patient word-of-mouth referrals.
To… #ophthalmology #eye #eyenews

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CDC pauses lab testing for dozens of diseases The CDC has paused diagnostic testing for more than two dozen infectious diseases —including rabies and pox viruses — according to the agency’s website. HHS spokesman Andrew Nixon told Healio that the pause is temporary while the CDC “evaluates these assays as part of our routine review to uphold our commitment to high-quality laboratory testing.” Nixon said the department expects “some of these tests will be available through CDC labs again in the coming weeks,” but he did not specify which ones. J. Glenn Morris Jr., MD, MPH&TM, professor and former director of the Emerging Pathogens

Ophthopedia Update: CDC pauses lab testing for dozens of diseases: The CDC has paused diagnostic testing for more than two dozen infectious diseases —including rabies and pox viruses — according to the agency’s website.
HHS spokesman Andrew Nixon told Healio that the… #ophthalmology #eye #eyenews

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ROP treatment receives orphan drug designation The FDA granted orphan drug designation to a triggering receptor expressed on myeloid cells 1 peptide inhibitor for the treatment of retinopathy of prematurity, according to a press release from SignaBlok. “Current therapeutic options (eye surgery, laser photocoagulation and eye injections of anti-VEGF drugs) are harmful, do not cure, have a high risk of serious complications and are often ineffective, suggesting an unmet need for new therapies,” Alexander B. Sigalov, PhD, president and founder of SignaBlok, told Healio. “SignaBlok addresses this urgent unmet need by introducing a novel,

Ophthopedia Update: ROP treatment receives orphan drug designation: The FDA granted orphan drug designation to a triggering receptor expressed on myeloid cells 1 peptide inhibitor for the treatment of retinopathy of prematurity, according to a press release from… #ophthalmology #eye #eyenews

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Glaukos helps patients, practices navigate Epioxa treatment Epioxa from Glaukos is the first epithelium-on corneal cross-linking treatment that has been FDA approved in the United States. While epi-on cross-linking has been common abroad for a number of years, Rajesh K. Rajpal, MD, said the procedure now has the potential to make a big difference for U.S. patients. “It’s a streamlined treatment because the UV light source is a higher-energy light combined with oxygen enrichment that enables the more efficient type II cross-linking. This helps overall for patients in terms of the amount of time their eyes are open and the amount of time they’re getting

Ophthopedia Update: Glaukos helps patients, practices navigate Epioxa treatment: Epioxa from Glaukos is the first epithelium-on corneal cross-linking treatment that has been FDA approved in the United States.
While epi-on cross-linking has been common abroad for a… #ophthalmology #eye #eyenews

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The price of being in our profession comes with responsibility Click here to read the Cover Story, “Paralympian initiates advocacy for eye care.” Winston Churchill once said, “The price of greatness is responsibility.” In modern eye care, that responsibility extends well beyond making the correct diagnosis or selecting the optimal surgical or medical therapy. Our obligation to patients does not end when we write the prescription or complete the procedure. It ends when the patient actually receives the care they need and benefits from it. The pace of innovation in eye care is extraordinary. We now have advanced diagnostics, precision surgery, novel implants,

Ophthopedia Update: The price of being in our profession comes with responsibility: Click here to read the Cover Story, “Paralympian initiates advocacy for eye care.”
Winston Churchill once said, “The price of greatness is responsibility.”
In modern eye care, that… #ophthalmology #eye #eyenews

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Study: Eye microbiome unchanged by contact lens wear The microbiome of the eye’s surface was not significantly different between contact lens wearers vs. non-wearers, suggesting other mechanisms may drive contact lens discomfort, according to a study in Microbiology Spectrum. “Contact lenses are worn by millions of people, yet the scientific literature contains conflicting reports about their impact on the microbial communities that are naturally present on the eye surface,” Oriane S. Kopp, of the department of ophthalmology at Bern University Hospital, Switzerland, and colleagues wrote. “Understanding the relationship between contact lens wear,

Ophthopedia Update: Study: Eye microbiome unchanged by contact lens wear: The microbiome of the eye’s surface was not significantly different between contact lens wearers vs. non-wearers, suggesting other mechanisms may drive contact lens discomfort, according to a… #ophthalmology #eye #eyenews

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Paralympian initiates advocacy for eye care As an athlete, Amy Dixon is used to overcoming adversity. She is a member of the U.S. Paratriathlon team and has competed in eight world championships and the Tokyo 2020 Paralympic Games. When she was 22 years old, she was diagnosed with multifocal choroiditis with panuveitis. Twelve years later, she received a diagnosis of neovascular glaucoma and steroid-induced glaucoma due to the years of steroid use to treat uveitis. “My doctors think the onset of my disease was probably when I was 10 years old,” she said. “I had rheumatic fever, a type of illness called erythema nodosum. At that time, I

Ophthopedia Update: Paralympian initiates advocacy for eye care: As an athlete, Amy Dixon is used to overcoming adversity.
She is a member of the U.S. Paratriathlon team and has competed in eight world championships and the Tokyo 2020 Paralympic Games. When she was 22… #ophthalmology #eye #eyenews

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Haag-Streit launches Metis 3D Digital Heads-Up Module worldwide The Metis 3D Digital Heads-Up Module from Haag-Streit is now available worldwide, according to a press release. The device, which debuted at the American Academy of Ophthalmology meeting in October 2025, expands on the company’s Metis 900 microscope with a digital 3D visualization platform. The platform uses a heads-up display to improve visualization and surgeon ergonomics. In an email statement, Mike Luley, director of global strategy and business development, visualization, Haag-Streit, told Healio that good ergonomics are essential to a surgeon’s health, and the heads-up platform builds on

Ophthopedia Update: Haag-Streit launches Metis 3D Digital Heads-Up Module worldwide: The Metis 3D Digital Heads-Up Module from Haag-Streit is now available worldwide, according to a press release.
The device, which debuted at the American Academy of Ophthalmology… #ophthalmology #eye #eyenews

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Yuvezzi for presbyopia now available in US Editor’s note: This is a developing story. Please check back soon for updates. Yuvezzi, an eye drop for the treatment of presbyopia, is now available in the U.S. According to a press release from Tenpoint Therapeutics, patients can fill prescriptions from eye care professionals for Yuvezzi (carbachol 2.75%/brimonidine tartrate 0.1% ophthalmic solution) through the company’s e-pharmacy partner, PHILRx, as well as local retail pharmacies. Yuvezzi is the first FDA-approved eye drop that uses two active ingredients to improve visual acuity and depth of focus: carbachol, which constricts the iris

Ophthopedia Update: Yuvezzi for presbyopia now available in US: Editor’s note: This is a developing story. Please check back soon for updates.
Yuvezzi, an eye drop for the treatment of presbyopia, is now available in the U.S.
According to a press release from Tenpoint… #ophthalmology #eye #eyenews

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Biogen to acquire Apellis for $5.6 billion Editor’s note: This is a developing story. Please check back soon for updates. Under the terms of a definitive agreement, Biogen will acquire Apellis for $41 per share in cash, or approximately $5.6 billion, according to a press release from Biogen. The acquisition includes two FDA-approved commercialized medicines: Syfovre (pegcetacoplan injection) for geographic atrophy and Empaveli (pegcetacoplan) for complement 3 glomerulopathy, primary immune complex membranoproliferative glomerulonephritis and paroxysmal nocturnal hemoglobinuria. The combined net sales for the two treatments in 2025

Ophthopedia Update: Biogen to acquire Apellis for $5.6 billion: Editor’s note: This is a developing story. Please check back soon for updates.
Under the terms of a definitive agreement, Biogen will acquire Apellis for $41 per share in cash, or approximately $5.6… #ophthalmology #eye #eyenews

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Elegrobart reduces proptosis in active thyroid eye disease A subcutaneous monoclonal antibody induced greater reductions in proptosis at 24 weeks than placebo for people with active thyroid eye disease, according to topline results from the REVEAL-1 trial. Elegrobart (Viridian Therapeutics) is a half-life extended monoclonal antibody designed to target the insulin-like growth I receptor. In the phase 3 REVEAL-1 trial, researchers assessed the efficacy of the therapy among 132 patients with active thyroid eye disease. Participants were randomly assigned to elegrobart every 4 weeks, elegrobart every 8 weeks or placebo. The primary outcome was proptosis

Ophthopedia Update: Elegrobart reduces proptosis in active thyroid eye disease: A subcutaneous monoclonal antibody induced greater reductions in proptosis at 24 weeks than placebo for people with active thyroid eye disease, according to topline results from the… #ophthalmology #eye #eyenews

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SYD-101 slows fast-progressing myopia in phase 3 trial SYD-101 significantly slowed the progression of myopia in younger children and quick progressors over 36 months, according to a press release from Sydnexis. “The STAR trial provides compelling evidence that low-dose atropine can meaningfully slow myopia progression, particularly in younger children who are progressing quickly,” lead presentation author Tina Rutar, MD, pediatric ophthalmologist and partner at Cataract and Laser Institute of Southern Oregon, told Healio. “These findings help clarify which patients are most likely to benefit and support a more targeted, proactive approach to

Ophthopedia Update: SYD-101 slows fast-progressing myopia in phase 3 trial: SYD-101 significantly slowed the progression of myopia in younger children and quick progressors over 36 months, according to a press release from Sydnexis.
“The STAR trial provides compelling… #ophthalmology #eye #eyenews

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Gene therapy reduces geographic atrophy lesion growth In a phase 2 trial, OCU410, a modifier gene therapy for geographic atrophy secondary to dry age-related macular degeneration, reduced lesion growth and size while slowing ellipsoid zone loss, according to a press release from Ocugen. “This outcome represents meaningful clinical and scientific validation of OCU410 but also further validation of our broader modifier gene therapy platform, giving us strong conviction as we advance into phase 3 and potential registrational pathway,” Shankar Musunuri, PhD, MBA, chairman, CEO and cofounder of Ocugen, told Healio. In the ArMaDa clinical trial, 51

Ophthopedia Update: Gene therapy reduces geographic atrophy lesion growth: In a phase 2 trial, OCU410, a modifier gene therapy for geographic atrophy secondary to dry age-related macular degeneration, reduced lesion growth and size while slowing ellipsoid zone loss,… #ophthalmology #eye #eyenews

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Five commonly missed retinal conditions and how to address them MIAMI — At Sunshine Eye and Retina, Rishi P. Singh, MD, shared advice with comprehensive ophthalmologists for addressing five commonly missed retinal diagnoses. “You guys see these patients all the time. You diagnose them first, and you then have to decide whether to refer them right away to us or to wait,” he said. One commonly missed diagnosis is proliferative diabetic retinopathy, Singh said. “This is an example where the [OCT angiography] can be very helpful,” he explained. “I’ll take an OCTA of the patient’s neovascularization of the disc, which will give me a reference point for why I’m

Ophthopedia Update: Five commonly missed retinal conditions and how to address them: MIAMI — At Sunshine Eye and Retina, Rishi P. Singh, MD, shared advice with comprehensive ophthalmologists for addressing five commonly missed retinal diagnoses.
“You guys see these… #ophthalmology #eye #eyenews

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Innovation, technology evolving in ophthalmology MIAMI — Innovation and technology are evolving to meet the need of “an aging population that needs our care now more than ever,” according to Matt Jensen, MBA. “We just don’t have enough doctors to get to them,” he said during a presentation at Sunshine Eye & Retina. “We are facing a time when we need our optometrist friends in their craft to operate at the very tip-top of their training and licensure. We need ophthalmologists to operate at the very tip-top of their craft and licensure so we can get to the patients who need us most.” Current financial challenges in ophthalmology include

Ophthopedia Update: Innovation, technology evolving in ophthalmology: MIAMI — Innovation and technology are evolving to meet the need of “an aging population that needs our care now more than ever,” according to Matt Jensen, MBA.
“We just don’t have enough doctors to… #ophthalmology #eye #eyenews

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Uveitis findings determine referral urgency MIAMI — Exam findings will show a comprehensive ophthalmologist when to refer a patient for uveitis, according to a speaker at Sunshine Eye & Retina. Sumit Sharma, MD, said clinicians should be able to recognize red flags that call for immediate referral to a uveitis or retina specialist, as well as signs to indicate they can comanage or treat these patients themselves. “The most important thing is really to start with a thorough history and review of systems,” Sharma said. “Looking at the patient's age, their sex, their ethnicity, where they live, their occupation is really important

Ophthopedia Update: Uveitis findings determine referral urgency: MIAMI — Exam findings will show a comprehensive ophthalmologist when to refer a patient for uveitis, according to a speaker at Sunshine Eye & Retina.
Sumit Sharma, MD, said clinicians should be able to… #ophthalmology #eye #eyenews

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GLP-1s may manage idiopathic intracranial hypertension MIAMI — For patients with idiopathic intracranial hypertension, GLP-1 receptor agonists may help with weight loss and play a role in reducing intracranial pressure, according to a speaker at Sunshine Eye & Retina. During a presentation, Julie Falardeau, MD, said that the majority of idiopathic intracranial hypertension (IIH) cases are non-vision threatening, meaning that the majority of patients will not require surgery. “They can be successfully managed medically,” she said. “So, what does it look like when you want to cut medically? Well, let’s cut the calories. Weight loss is one of the

Ophthopedia Update: GLP-1s may manage idiopathic intracranial hypertension: MIAMI — For patients with idiopathic intracranial hypertension, GLP-1 receptor agonists may help with weight loss and play a role in reducing intracranial pressure, according to a speaker at… #ophthalmology #eye #eyenews

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Identify early dysfunction to preserve retinal reserve Many retinal diseases begin long before patients experience noticeable vision loss. Clinicians frequently manage patients with early age-related macular degeneration, diabetes or glaucoma who maintain normal visual function despite underlying disease processes. This clinical reality raises an important question: Are we detecting retinal disease at the point at which we have the greatest opportunity to preserve vision? Emerging evidence suggests that structural retinal damage often represents a relatively late stage of disease progression. Functional abnormalities and metabolic stress regularly

Ophthopedia Update: Identify early dysfunction to preserve retinal reserve: Many retinal diseases begin long before patients experience noticeable vision loss.
Clinicians frequently manage patients with early age-related macular degeneration, diabetes or glaucoma who… #ophthalmology #eye #eyenews

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FDA loosens regulatory oversight for digital health innovation LOS ANGELES — It is important for primary care providers to understand new federal regulations surrounding wearables, wellness and clinical decision support, especially because it will impact reimbursement, according to a speaker here. Aubrey Shick, a former official in the FDA’s Digital Health Center of Excellence, offered a presentation on FDA’s January 2026 updates, and how they “change the game” for wearables, clinical decision support and wellness at Cedars-Sinai’s eighth annual iteration of its Virtual Medicine Conference, vMed. Healio spoke with Shick to learn more about the changes, the

Ophthopedia Update: FDA loosens regulatory oversight for digital health innovation: LOS ANGELES — It is important for primary care providers to understand new federal regulations surrounding wearables, wellness and clinical decision support, especially because it will… #ophthalmology #eye #eyenews

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Ophthalmologists can act as ‘first responders’ for stroke MIAMI — Ophthalmologists should consider themselves first responders for patients experiencing stroke, according to a presenter. At Sunshine Eye & Retina, Priya Vakharia, MD, discussed the eye care specialist’s role when faced with this scenario. “Patients with central retinal artery occlusions (CRAO) present to our office and ... your office,” she said. It is important to know that the management of strokes has changed. This condition is the most common cause of disability in U.S. adults and the fifth leading cause of death, Vakharia said. There are approximately 795,000 strokes each year

Ophthopedia Update: Ophthalmologists can act as ‘first responders’ for stroke: MIAMI — Ophthalmologists should consider themselves first responders for patients experiencing stroke, according to a presenter.
At Sunshine Eye & Retina, Priya Vakharia, MD, discussed the… #ophthalmology #eye #eyenews

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Ophthalmologists need to identify different types on ptosis MIAMI — Ophthalmologists need to understand types of ptosis to identify and treat the condition, according to a speaker at Sunshine Eye & Retina. According to Jennifer Murdock, MD, a number of factors lead to ptosis, and not all ptosis needs to be corrected. It is important to distinguish between dermatochalasis, blepharoptosis, brow ptosis or a possible combination. “Identifying the type of ptosis is your first and foremost concern when these patients come to your office,” she said. “Look at best management options and consider special disease comorbidities.” According to Murdock,

Ophthopedia Update: Ophthalmologists need to identify different types on ptosis: MIAMI — Ophthalmologists need to understand types of ptosis to identify and treat the condition, according to a speaker at Sunshine Eye & Retina.
According to Jennifer Murdock, MD, a… #ophthalmology #eye #eyenews

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Eyelid malposition requires precise diagnosis MIAMI — The precise diagnosis of eyelid malposition drives surgical and treatment success, according to a speaker at Sunshine Eye & Retina. Chad Zatezalo, MD, said there are several classifications of lid malposition. One malposition is entropion. Zatezalo said this can be classified as involutional, spastic, cicatricial or congenital. “When you’re evaluating for the entropion, you want to use the snap technique,” he said. “There are two vectors that are disrupted. You have the lateral, or the horizontal, and the vertical vector. So, the key to fixing these is balancing those vectors and

Ophthopedia Update: Eyelid malposition requires precise diagnosis: MIAMI — The precise diagnosis of eyelid malposition drives surgical and treatment success, according to a speaker at Sunshine Eye & Retina.
Chad Zatezalo, MD, said there are several classifications of… #ophthalmology #eye #eyenews

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Most US workers have symptoms related to digital eyestrain Most workers in the U.S. reported dealing with dry eyes, headaches and other symptoms related to using digital screens at work, according to VSP Vision Care. Symptoms of digital eyestrain were reported in a survey by 71% of desk workers and 59% of non-desk workers. The survey, conducted by Workplace Intelligence, included 800 human resource and benefits leaders and 1,200 full-time employees in the U.S., both desk based and non-desk based. The findings come as screen time continues to increase, drawing attention to the potential ocular health effects. Desk workers said they spent an average of

Ophthopedia Update: Most US workers have symptoms related to digital eyestrain: Most workers in the U.S. reported dealing with dry eyes, headaches and other symptoms related to using digital screens at work, according to VSP Vision Care.
Symptoms of digital eyestrain… #ophthalmology #eye #eyenews

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Global deaths from early-onset cancer fall significantly Early-onset cancer incidence increased 3% globally during the past 3 decades, but mortality from these malignancies dropped 17%. “It’s good news,” Rupayan Kundu, MD, resident physician at Cleveland Clinic, told Healio, comparing the “subtle” increase in diagnoses with the significant reduction in deaths. However, obesity remains a substantial concern in early-onset disease, as mortality related to high BMI increased nearly 93% between 1990 and 2021. “There is a global epidemic in obesity, and we are seeing the effect right now,” Kundu said. Early-onset cancer has become a focus of extensive

Ophthopedia Update: Global deaths from early-onset cancer fall significantly: Early-onset cancer incidence increased 3% globally during the past 3 decades, but mortality from these malignancies dropped 17%.
“It’s good news,” Rupayan Kundu, MD, resident physician at… #ophthalmology #eye #eyenews

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White House delays picking CDC director despite deadline The White House did not nominate a new CDC director on Wednesday despite coming up against a federally imposed deadline to do so. White House Spokesperson Kush Desai told Healio that NIH Director Jay Bhattacharya, MD, PhD, will continue to perform the duties of acting CDC director until a permanent replacement is selected. “Restoring competence and confidence in CDC decision-making remains a top priority for the White House after the Biden administration’s COVID excesses,” Desai said. “Dr. Jay Bhattacharya’s leadership at the CDC is a great service to the country, and he has now been delegated

Ophthopedia Update: White House delays picking CDC director despite deadline: The White House did not nominate a new CDC director on Wednesday despite coming up against a federally imposed deadline to do so.
White House Spokesperson Kush Desai told Healio that NIH… #ophthalmology #eye #eyenews

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Elios system reduces IOP in open-angle glaucoma Editor’s note: This is a developing news story. Please check back soon for updates. In a pivotal clinical trial, an excimer laser procedure reduced IOP in patients with glaucoma, according to a press release from Bausch + Lomb. The Elios system reduced patients’ IOP by creating microchannels in the trabecular meshwork to improve aqueous flow. Researchers conducted a prospective study including 318 patients at 20 U.S. sites who were previously diagnosed with mild to moderate primary open-angle glaucoma, for which they were taking glaucoma medications, and cataracts. The co-primary endpoints

Ophthopedia Update: Elios system reduces IOP in open-angle glaucoma: Editor’s note: This is a developing news story. Please check back soon for updates.
In a pivotal clinical trial, an excimer laser procedure reduced IOP in patients with glaucoma, according to a press… #ophthalmology #eye #eyenews

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Laser eye surgeons should be vigilant for P. lilacinum infection Three patients contracted fungal keratitis after undergoing laser eye surgery at a New York City clinic in December 2024, according to a report in Morbidity and Mortality Weekly Report. When the patients reported eye pain and vision loss after surgery, the clinic sent corneal specimens to a clinical laboratory that returned findings of fungal elements on microscopy. Cultures later revealed Purpureocillium lilacinum in two of the patient specimens. The laboratory then notified the New York City Health Department, according to the report. Michelle E. Chang, MD, and colleagues wrote that the first

Ophthopedia Update: Laser eye surgeons should be vigilant for P. lilacinum infection: Three patients contracted fungal keratitis after undergoing laser eye surgery at a New York City clinic in December 2024, according to a report in Morbidity and Mortality Weekly… #ophthalmology #eye #eyenews

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