FEBS Press Creatine deficiency leads to severe neurodevelopmental disorders. In the brain, creatine is synthesized by oligodendrocytes to supply neighboring neurons. While SLC6A8 mediates neuronal uptake, the c...

A creatine efflux transporter in oligodendrocytes #FEBSJ #MassSpec febs.onlinelibrary.wiley.com/doi/10.1111/...

FEBS Press Cathepsin D (CTSD), primarily intracellular, is crucial for normal cellular processes but can be secreted extracellularly in diseases like metabolic dysfunction-associated steatohepatitis (MASH), ass....

Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction-associated steatohepatitis #FEBSJ #MassSpec febs.onlinelibrary.wiley.com/doi/10.1111/...

Therapeutic opportunities for #Senolysis in cardiovascular disease

#Atherosclerosis
#MyocardialInfarction
#HeartFailure
#CardioOncology
#PulmonaryHypertension

Jesús Gil lab #FEBSJ 2023
febs.onlinelibrary.wiley.com/doi/full/10....