Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice - Nature Communications The circadian clock protein REV-ERBα has been implicated in neuroinflammation but mechanisms are poorly understood. Here, the authors show that microglial REV-ERBα regulates inflammatory signaling and...

Identifying microglial REV-ERBα as a key regulator of inflammation & lipid droplet formation, driving #Tau pathology in male mice. Our #FITCTau was used to track microglial uptake of extracellular Tau after #aggregation, revealing impaired phagocytosis in REV-ERBα-deficient microglia.

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