Key Role of Pro230 in the Hinge Region on the Architecture and Function of IgG1 Immunoglobulin G (IgG) is a multifunctional glycoprotein essential for immune defense and widely used as a therapeutic due to its antigen specificity and effector functions. However, the inherent flex...

Deleting a single amino acid in #IgG lower hinge alter sits assembly and immune signaling, e.g. impair interactions with #Fcγ receptors. bit.ly/4rsdrJo [open access]