#FibroAdipogenicProgenitor #FAP

Pdgfra+ FAP IGF-1 KO🐭
👉No baseline #SkeletalMuscle anomalies in 1 mo
👉⏬FAP proliferation ⏫FAP #Senescence⏬Pax7+ MuSc⏬Myofiber size in BaCl2 SkM injury
👉Impaired fibrotic AND adipogenic capacities of FAP in vivo

#MyoSky
bioRxiv 2025
www.biorxiv.org/content/10.1...

A Cellular Dictionary of Developing Human Heart👹
#SpatialTranscritomics #Visium
+150-gene #InSituSequencing
~70k spots, 16 hearts 6-12th p.c.w

There are even Nerve #FibroAdipogenicProgenitor & #Pericyte😆

bioRxiv 2024
www.biorxiv.org/content/10.1...

4/7
#FibroAdipogenicProgenitor in PAD

⏫Cytokine response/Proliferation
⏬#AxonGuidance (ROBO1/SEMA3C/5A/EFNA5)/Negative regulators of TGFβ (LTBP1/FBN1/SMURF2/ITGA8)