Cutting-Edge Computational Study Provides ‘Gut Check’ to How We Thought Proteins Function Cutting-Edge Computational Study Provides ‘Gut Check’ to How We Thought Proteins Function on Simons Foundation

In 2023, #FlatironCCB researchers used AI-powered tools to map proteins in the human gut microbiome, ultimately challenging the traditional view of the relationship between protein sequence, structure and function: https://bit.ly/4bTIzwi #CitizenScienceMonth #science #biology #ActsofScience

The Machinery That Helps Divide Your Cells Self-Organizes Like an Active Liquid Crystal Flatiron Institute researchers found that a theory that treats chromosome-separating cellular structures called spindles as active liquid crystals explains how they self-organize to carry out their fu...

#FlatironCCB scientists and experimental collaborators tested a theory that treats chromosome-separating cellular structures called spindles as active liquid crystals: www.simonsfoundation.org/the-machinery-that-helps... #science

graphic entitled 'Mini Motors'

New research in Nature Physics from #FlatironCCB's Henry Mattingly and Yuhai Tu proposes a different mechanism for how swimming bacteria change direction: www.simonsfoundation.org/2026/01/08/a-tug-of-war-... #science #biology

HumanBase: an interactive AI platform for human biology - Nature Methods Nature Methods - HumanBase: an interactive AI platform for human biology

This new Nature Methods paper presents HumanBase, an AI-powered platform for driving discoveries in genomic data from #FlatironCCB: https://www.nature.com/articles/s41592-025-02994-8 #science #biology

New research from #FlatironCCB scientists proposes a new explanation for how bacteria change direction: an energy-consuming, mechanical tug-of-war. Read more: www.simonsfoundation.org/2026/01/08/a-tug-of-war-... #science #biology

From Ring to Keyhole: Modeling How Tissues Mold the Fruit Fly's Gut A study on the fruit fly gut led by Flatiron Institute researchers gives insight into how tissues are shaped by bumping into their neighbors.

A new study from #FlatironCCB researchers uses cutting-edge computational modeling of the fruit fly gut to lay the groundwork for understanding how organs and tissues take shape across many species: www.simonsfoundation.org/from-ring-to-keyhole-mod...

#FlatironCCB biologists and collaborators examined the embryo of a well-studied organism — the fruit fly — to track how its hindgut (shown here in red) develops: www.simonsfoundation.org/2025/11/17/from-ring-to-... #science #biology

From Ring to Keyhole: Modeling How Tissues Mold the Fruit Fly’s Gut A study on the fruit fly gut led by Flatiron Institute researchers gives insight into how tissues are shaped by bumping into their neighbors.

Researchers from @flatironinstitute.org and @princeton.edu demonstrated how mechanical forces from surrounding tissues can shape the fruit fly gut: www.simonsfoundation.org/2025/11/17/from-ring-to-... #science #biology #FlatironCCB

From Ring to Keyhole: Modeling How Tissues Mold the Fruit Fly’s Gut A study on the fruit fly gut led by Flatiron Institute researchers gives insight into how tissues are shaped by bumping into their neighbors.

#FlatironCCB researchers and collaborators demonstrated how mechanical forces from surrounding tissues can shape the fruit fly gut: www.simonsfoundation.org/2025/11/17/from-ring-to-... #science #biology

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#FlatironCCB's recent ScoRe meeting highlighted quantitative experimental work and mathematical models for germ cell development and for early developmental stages post-fertilization. Thanks to all who joined us! #science #biology

Careers Careers on Simons Foundation

There are just over two weeks to apply to our #FlatironCCB Flatiron Research Fellow postdoc positions! Deadline is 11/15: www.simonsfoundation.org/flatiron/careers/ #science #biology

Careers Careers on Simons Foundation

#FlatironCCB is hiring! Check out our open positions in computational biology, including postdoc fellowships: www.simonsfoundation.org/flatiron/careers/ #biology #science

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Last week, #FlatironCCM and #FlatironCCB held a Computational Cryo-EM Workshop that focused on methods for 3D heterogeneity analysis including deep learning and statistical techniques in cryo-EM. #science #biology #math

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A new study from Princeton and @flatironinstitute.org researchers uses @sparkforautism.bsky.social data to reveal four distinct subclasses of autism. The work could open the door for more precise diagnoses and personalized support: www.simonsfoundation.org/2025/07/09/n... #science #FlatironCCB

PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

New paper from #FlatironCCN and #FlatironCCB scientist Yuhai Tu in @pnas.org: Representational drift and learning-induced stabilization in the piriform cortex. Read here: www.pnas.org/doi/10.1073/... #neuroscience #science

New Study Reveals Subclasses of Autism by Linking Traits to Genetics New Study Reveals Subclasses of Autism by Linking Traits to Genetics on Simons Foundation

#FlatironCCB scientists Natalie Sauerwald, Olga Troyanskaya and colleagues leveraged @sparkforautism.bsky.social data to reveal four distinct groups that link autism-related traits with underlying genetics. Read more: www.simonsfoundation.org/2025/07/09/n... #science #biology #autismresearch

New Study Reveals Subclasses of Autism by Linking Traits to Genetics New Study Reveals Subclasses of Autism by Linking Traits to Genetics on Simons Foundation

A new Nature Genetics study from #FlatironCCB and Princeton University researchers leverages data to identify 4 distinct groups based on links autism-related traits and underlying genetics: www.simonsfoundation.org/2025/07/09/n... #science #biology #autismresearch

The short film "Molecular Duet" brings the dynamic world of microtubules to life. A collaboration between @flatironinstitute.org researcher Mahsa Mofidi and filmmaker Anne Sofie Nørskov. Watch in full: www.simonsfoundation.org/2025/07/16/w... #science #biology #film #FlatironCCB

From #FlatironCCB scientist Bargeen Turzo and filmmaker Grace Zhang, "How to Connect Two Bodies" is an experimental documentary exploring the invisible choreography in meaningful connections of objects across various scales. Watch in full: www.simonsfoundation.org/2025/07/09/w... #science #film

As part of our Symbiosis program, #FlatironCCB researcher Vikram Mulligan teamed up with filmmaker John Marty to create "Beyond the 20," a #science essay film exploring the boundary between NYC's built environment and molecular engineering design challenges. www.simonsfoundation.org/2025/06/25/w...

Trying to anticipate how bacteria will spread is like predicting the flight of a leaf in a windstorm — it’s complicated and chaotic. However, a new #FlatironCCB study presents a computational method for predicting how bacteria navigate obstacles: www.simonsfoundation.org/2025/03/21/n... #science

Heuristic energy-based cyclic peptide design Author summary Cyclic peptides are circular chains of amino acid residues that are promising candidates for new therapeutic drugs. Current FDA approved cyclic peptide-based drugs are mostly derived fr...

Qiyao Zhu from the Biomolecular Design team at the #FlatironCCB has a new paper out on tools for modeling long, heterochiral, cyclic peptides: dx.plos.org/10.1371/jour...

Applications coming soon!
@flatironinstitute.org

New Model Predicts How Bacteria Navigate Obstacles to Spread A Flatiron Institute scientist has developed the first analytical model for predicting how bacteria spread in environments filled with obstacles.

ICYMI: #FlatironCCB scientist @henryhmattingly.bsky.social developed the first analytical model for predicting how bacteria spread in obstacle-laden environments. Read more: www.simonsfoundation.org/2025/03/21/n... #science #biology

Three small video stills that show the path a simulated bacteria takes through an obstacle-filled liquid.

A new theoretical model developed by #FlatironCCB scientist @henryhmattingly.bsky.social predicts how bacteria disperse in crowded spaces, opening the door for strategies to control their spread. Read more: www.simonsfoundation.org/2025/03/21/n... #science #biology

New Model Predicts How Bacteria Navigate Obstacles to Spread A Flatiron Institute scientist has developed the first analytical model for predicting how bacteria spread in environments filled with obstacles.

A new model developed by #FlatironCCB scientist @henryhmattingly.bsky.social predicts how bacteria spread in obstacle-laden environments. The results, published in @pnas.org, have implications for stopping the spread of harmful bacteria: www.simonsfoundation.org/2025/03/21/n... #biology #science

Visual graphic of membrane protein simulation

#FlatironCCB scientist @sonyahanson.bsky.social was a guest editor for the Journal of Physical Chemistry B's new Membrane Protein Simulations Special Issue. Read here: pubs.acs.org/toc/jpcbfk/1... #science #biology

Image that reads "It's a robust pattern that comes from a very simple rule, and it's just something that no one had really thought to measure before." with a green circle

Researchers at the @flatironinstitute.org recently discovered how dividing cells adapt to crowded environments by slowing their growth, informing strategies for curbing the spread of dangerous microorganisms. www.simonsfoundation.org/2024/10/10/c... #science #biology #FlatironCCB

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An audience in an auditorium

Our recent Presents event saw #FlatironCCB biophysicist Jasmin Imran Alsous and clinical psychologist Orna Guralnik explore what the biological intricacies of cell cooperation can tell us about human connections. Learn more about Presents: www.simonsfoundation.org/sf-events/?t...

📷: Arin Sang-Urai