#NICE #type2diabetes #NICEguidance #NHSsavings #dapagliflozin #NICEfinalguidance #SGLT2inhibitor #flozins #NHScostsavings #SGLT2medicines #clinicallyequivalentgenerics #GLP1receptoragonists #NICEguidelines #healthinequalities #NHSType2DiabetesPathtoRemissionProgramme
zurl.co/0vbyO
I think this data is interesting and mildly reassuring.
I feel like #flozins are fairly benign (no safety signals), but do they work in transplant patients like CKD patients…that remains to be determined #NephJC
Do you think it would be possible to get the ethical committee/ trial board approval of your institution to start a long term CV outcome trial on #Flozins in transplant ?
#NephJC
Also because #flozins do not seem to follow any of the other mechanistic principles as in CKD patients, it seems scary to just accept the eGFR dip as due to them alone. We would end up evaluating for other causes. #NephJC
T0j
The INFINITI trial has set out to answer this very question.
Let’s see if #Flozins can go to INFINITY AND BEYOND! (Disclaimer: Disney has not specifically endorsed #flozin use) #NephJC
T0f
🔍Proposed mechanisms of action of the #flozins include
-restoration of tubuloglomerular feedback
-intraglomerular pressure reduction
-osmotic diuresis
-improved tubular energetics.
Do these mechanisms also work in transplanted kidneys?
#NephJC
⏰30 min before the #NephJC chat
There has been limited research on SGLT2i in renal transplant recipients till date, and this is the compilation of currently available data. #NephJC
Are you pumped to know how and how well #Flozins work in transplanted patients?
Let's deep dive in a few minutes!
The Effect of SGLT2 Inhibitors aka #Flozins on Blood Pressure in Relation to Baseline Kidney Function: A Systematic Literature Review and Data Analysis
🔗 academic.oup.com/ajh/article-... 🔒
Here is the VA for the INFINITI study of SGLT2i in transplant patients by @glomerican.bsky.social #NephSky #Flozins #Flozination
www.nephjc.com/news/2026/2/8/infiniti-the-visual-abstract
Hey #NephSky
2/10/26 at 9 pm EST we'll discuss
#Flozinating into the Future & Beyond...
SGLT2i in kidney transplant recipients.
What's the latest evidence of risk/benefit?
Do #Flozins act mechanistically the same in de-innervated kidneys?
Come chat.
www.nephjc.com/news/inifinti-flozins-transplant
For #flozins I would add this individual-level meta:
1. Hypothesizing: they work across subgroups, in patients with lower UACR, in pts with HF, etc
2. Shows us that we don't completely understand their mechanisms
pubmed.ncbi.nlm.nih.gov/41082889/
Keto-analog supplements are just about as expensive as #flozins. Don't blame lack of profit rather blame a supplement industry that is not held accountable to research like the pharmaceutical industry is
#Flozins in ADPKD. Interesting VA data suggesting that they may be safe and have a role in renal preservation
journals.lww.com/cjasn/fullte...
In Norway🇳🇴, 4 years after DAPA-HF, 85% of those with reduced ejection fraction heart failure get an SGLT2i. In the US🇺🇸, it's under 30%. #gdmt #flozins #cardiosky
www.hcplive.com/view/study-h...
onlinelibrary.wiley.com/doi/10.1002/...
I start #flozins before I maximize the RASi to gain the extra bit of kaluresis and hopefully tolerate a bit more RASi #NephJC
Christos Argyropoulos,
University of New Mexico
Heavy user of both #flozins and #nsMRA >> your grandpa's #MRA (only in those who cannot get the former)
#Nephjc
CONFIDENCE on go!
Ready to catch 🆙 new wisdom of FINE & #flozins together?
Join us tomorrow #NephJC #NephSky #MedSky
Some add #flozins to the water, for 🇩🇰 probably ozempic is as cheap as the water #nephjc
www.dovepress.com/semaglutide-...
Among persons with both #CKD and #T2D, initial therapy with #MRA plus #SGLT2i #Flozins led to a greater reduction in the urinary albumin-to-creatinine ratio than either treatment alone.
The results are impressive, will it change practice?
www.nejm.org/doi/full/10....
@nejm.org
#MedSky #CONFIDENCE
It seems the usual #EBM suspects are making snarky comments about #CONFIDENCE similar to their comments about #flozins #sglt2i in the years leading up to CREDENCE/DAPA-CKD/EMPA-KIDNEY.
It was obvious then (and it is now) that they don't understand how UACR works as a biomarker
It seems the usual #EBM suspects are making snarky comments about #CONFIDENCE similar to their comments about #flozins #sglt2i in the years leading up to CREDENCE/DAPA-CKD/EMPA-KIDNEY.
It was obvious then (and it is now) that they don't understand how UACR works as a biomarker
If I were you I'd start praying that the #flozins and the #MRAs hold the fort. If not, not good things will happen by the mid 2030s
