Specifically, we decided to compare (i) #intact #aging (the baseline), (ii) #VCD injections 💉 starting up to middle-age, and (iii) #haploinsufficiency 🧬 of #Foxl2. Importantly, each model revealed specific aspects, distinct in each model, that are most reminiscent of human ovarian aging. 3/9

Somatic Sex Reprogramming of Adult Ovaries to Testes by FOXL2 Ablation In mammals, the transcription factor SRY, encoded by the Y chromosome, is normally responsible for triggering the indifferent gonads to develop as testes rather than ovaries. However, testis different...

#DevelopmentalBiology Did you know that gonad organization is not stable throughout life? 😱 I didn’t. #Foxl2 seems to be the maintainer of ovarian identity. When Foxl2 is deleted in adult-stage ovaries (in mice 🐭) the ovary is transformed into testis. 🤯 www.cell.com/fulltext/S00...