Notch3 destabilizes regulatory T cells to drive autoimmune neuroinflammation in multiple sclerosis Benamar et al. demonstrate that Notch3+ Treg cells are increased in multiple sclerosis and in EAE. They are induced in the gut by microbiota and translocate to the CNS to degenerate into pathogenic Th...

#WeekendRead! #FroendsOrFoes?! Benamar, Chatila &co identify @cp-immunity.bsky.social a #GutBrain axis leading to microbiota- & TLR-dependent induction of Notch3+ Tregs in the gut that in multiple sclerosis migrate to the CNS & interacting with microglia become pathogenic Th17 cells!