The cGAS-STING DNA-sensing pathway in #Atherosclerosis

Exogenous: Pathogen/Plasmid DNA
Endogenous: mtDNA, cfDNA, micronuclei, chromatin bridge, retrotransposon transcript, DNA damage▶️cytosolic DNA

Table cGAS/STING inhibitors

#FrontCVMed 2025
www.frontiersin.org/journals/car...

#Hypertension #AorticDissection #AorticRupture

Myh11 R247C/R247C🐭+L-NAME
👉>1/3 mortality in 16-wk hypertension
👉Aortic root dissection/rupture WITHOUT aneurysm
👉⏬#SmoothMuscleCell-Elastin tethering
👉Hyperactive FAK

#AortaEd
#FrontCVMed 2025
www.frontiersin.org/journals/car...